A graphene foam/zirconium-based metal–organic framework composite (GF/UiO-66) was synthesised and then employed to modify glassy carbon electrodes (GCE). These modified electrodes were successfully used for the simultaneous detection and determination of acetaminophen (AC) and tryptophan (TRYP). The combination of GF and UiO-66 endowed the electrodes with a large surface area, good biological compatibility and stability as well as high selectivity and sensitivity. The linear calibration plots for AC and TRYP were obtained over the range of 0.5–200 µM (R2 = 0.999) and 0.5–113 µM (R2 = 0.999) with detection limits of 0.07 µM and 0.06 µM, respectively. The modified electrodes were successfully applied for the determination of AC and TRYP in a pharmaceutical preparation and urine, respectively.
Reference:
Kemmegne-Mbouguen, J.C. (et.al.). 2020. Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode. New Journal of Chemistry, v44(30), pp 13108-13117.
Kemmegne-Mbouguen, J., Tchoumi, F., Mouafo-Tchinda, E., Langmi, H., Bambalaza, S. E., Musyoka, N. M., ... Mokaya, R. (2020). Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode. http://hdl.handle.net/10204/11658
Kemmegne-Mbouguen, JC, FP Tchoumi, E Mouafo-Tchinda, HW Langmi, Sonwabo E Bambalaza, Nicholas M Musyoka, C Kowenje, and R Mokaya "Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode." (2020) http://hdl.handle.net/10204/11658
Kemmegne-Mbouguen J, Tchoumi F, Mouafo-Tchinda E, Langmi H, Bambalaza SE, Musyoka NM, et al. Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode. 2020; http://hdl.handle.net/10204/11658.
Copyright: 2020 Royal Society of Chemistry. This is the preprint version of the work. For access to the published version, kindly visit the publisher's website.
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