6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.
Reference:
Mabank, T., Alexandre, K.B., Pelly, S.C., Green, I.R. and Van Otterlo, W.A.L. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation. ARKIVOC, July 2019, Part 4, pp 245-279.
Mabank, T., Alexandre, K. B., Pelly, S., Green, I., & Van Otterlo, W. (2019). Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation. http://hdl.handle.net/10204/11303
Mabank, T, Kabamba B Alexandre, SC Pelly, IR Green, and WAL Van Otterlo "Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation." (2019) http://hdl.handle.net/10204/11303
Mabank T, Alexandre KB, Pelly S, Green I, Van Otterlo W. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation. 2019; http://hdl.handle.net/10204/11303.
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