Author:Sari-Ak, D; Alomari, O; Shomali, RA; Lim, J; Thimiri Govindaraj, Deepak BDate:Dec 2022The baculovirus expression vector systems (BEVS) have been widely used for the recombinant production of proteins in insect cells and with high insert capacity. However, baculovirus does not replicate in mammalian cells; thus, the BacMam ...Read more
Author:Kenmogne, Vanelle L; Nweke, EE; Takundwa, Mutsa M; Fru, PN; Thimiri Govindaraj, Deepak BDate:Oct 2022Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular ...Read more
Author:Nweke, EE; Suleman, Essa; Du Plessis, M; Thimiri Govindaraj, Deepak BDate:Aug 2021In this book chapter, we focus on application of genome annotation and analysis of microbes for synthetic biology and cancer biology research. We particularly emphasised on application of microbial genomics in synthetic biology and cancer ...Read more
Author:Gong, X; Srivastava, V; Naicker, Previn; Khan, A; Ahmad, ADate:Mar 2023Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ...Read more
Author:Gong, X; Srivastava, V; Naicker, Previn; Khan, A; Ahmad, ADate:Mar 2023Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ...Read more
Author:Alexander, Kabamba; Malatji, Kanyane; Mulaudzi, TakalaniDate:May 2020Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased ...Read more
Author:Tumba, NL; Naicker, Previn; Stoychev, Stoyan H; Killick, MA; Owen, GR; Papathanasopoulos, MADate:Jul 2022The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as ...Read more
Author:Thimiri Govindaraj, Deepak BDate:Jan 2022Global bio-foundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. Global bio-foundry Alliance plays the key role in the ...Read more
Author:Thimiri Govindaraj, Deepak BDate:Mar 2023Background: Global bio-foundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. Global bio-foundry Alliance plays the key ...Read more
Author:Malatji, Kanyane; Singh, Advaita A; Thobakgale, C; Alexandre, KabambaDate:Sep 2023Currently there are diagnostic tests available for human immunodeficiency virus (HIV) and tuberculosis (TB); however, they are still diagnosed separately, which can delay treatment in cases of co-infection. Here we report on a multiplex ...Read more
Author:Nweke, EE; Thimiri Govindaraj, Deepak BDate:Feb 2021In this chapter, we delineated the methods of CRISPR technology that has been used for the development of engineered insect cell line. We elaborated on how CRISPR/Cas9 genome editing in Drosophila melanogaster, Bombyx mori, Spodoptera frugiperda ...Read more
Author:Nweke, EE; Thimiri Govindaraj, Deepak BDate:Feb 2021One of the critical Global challenges in achieving the UN Sustainable Development Goals 3 Good Health and Well Being is optimizing drug discovery and translational research for unmet medical need in both communicable and non-communicable ...Read more
Author:Abolnik, C; O’Kennedy, Martha M; Murphy, MA; Wandrag, BDRDate:Jun 2022Outbreaks caused by Goose/Guangdong H5 highly pathogenic avian influenza (HPAI)-lineage viruses continue to occur in unprecedented numbers throughout Eurasia, the Middle East and Africa, causing billions of dollars in economic losses and the ...Read more
Author:Abolnik, C; O'Kennedy, Martha M; Murphy, MA; Wandrag, DBRDate:Jun 2022Outbreaks caused by Goose/Guangdong H5 highly pathogenic avian influenza (HPAI)-lineage viruses continue to occur in unprecedented numbers throughout Eurasia, the Middle East and Africa, causing billions of dollars in economic losses and the ...Read more
Author:Sepotokele, KM; O’Kennedy, Martha M; Hayes, MC; Wandrag, DBR; Smith, P; Abolnik, CDate:Oct 2023Infectious bronchitis (IB) Gammacoronavirus causes a highly contagious respiratory disease in chickens that is listed by the World Organisation for Animal Health (WOAH). Its high mutation ability has resulted in numerous variants against which ...Read morecbnd