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Microfluidic cartridges for automated, point-of-care blood cell counting

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dc.contributor.author Smith, Suzanne
dc.contributor.author Madzivhandila, Phophi
dc.contributor.author Sewart, R
dc.contributor.author Govender, Ureshnie
dc.contributor.author Becker, H
dc.contributor.author Roux, Pieter
dc.contributor.author Land, Kevin J
dc.date.accessioned 2017-09-07T12:05:21Z
dc.date.available 2017-09-07T12:05:21Z
dc.date.issued 2016-11
dc.identifier.citation Smith, S., Madzivhandila, P., Sewart, R. et al. 2016. Microfluidic cartridges for automated, point-of-care blood cell counting. Journal of Laboratory Automation, vol. 22(2): 176-185. doi: 10.1177/2211068216677820 en_US
dc.identifier.issn 2211-0682
dc.identifier.uri doi: 10.1177/2211068216677820
dc.identifier.uri http://jla.sagepub.com/content/early/2016/11/16/2211068216677820.abstract
dc.identifier.uri http://hdl.handle.net/10204/9546
dc.description Copyright: 2016 Society for Laboratory Automation and Screening. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, kindly consult the publisher's website. en_US
dc.description.abstract Disposable, low-cost microfluidic cartridges for automated blood cell counting applications are presented in this article. The need for point-of-care medical diagnostic tools is evident, particularly in low-resource and rural settings, and a full blood count is often the first step in patient diagnosis. Total white and red blood cell counts have been implemented toward a full blood count, using microfluidic cartridges with automated sample introduction and processing steps for visual microscopy cell counting to be performed. The functional steps within the microfluidic cartridge as well as the surrounding instrumentation required to control and test the cartridges in an automated fashion are described. The results recorded from 10 white blood cell and 10 red blood cell counting cartridges are presented and compare well with the results obtained from the accepted gold-standard flow cytometry method performed at pathology laboratories. Comparisons were also made using manual methods of blood cell counting using a hemocytometer, as well as a commercially available point-of-care white blood cell counting system. The functionality of the blood cell counting microfluidic cartridges can be extended to platelet counting and potential hemoglobin analysis, toward the implementation of an automated, point-of-care full blood count. en_US
dc.language.iso en en_US
dc.publisher SAGE Publications Ltd en_US
dc.relation.ispartofseries Worklist;17977
dc.subject Microfluidics en_US
dc.subject Point-of-care diagnostics en_US
dc.subject Blood cell counting en_US
dc.title Microfluidic cartridges for automated, point-of-care blood cell counting en_US
dc.type Article en_US
dc.identifier.apacitation Smith, S., Madzivhandila, P., Sewart, R., Govender, U., Becker, H., Roux, P., & Land, K. J. (2016). Microfluidic cartridges for automated, point-of-care blood cell counting. http://hdl.handle.net/10204/9546 en_ZA
dc.identifier.chicagocitation Smith, Suzanne, Phophi Madzivhandila, R Sewart, Ureshnie Govender, H Becker, Pieter Roux, and Kevin J Land "Microfluidic cartridges for automated, point-of-care blood cell counting." (2016) http://hdl.handle.net/10204/9546 en_ZA
dc.identifier.vancouvercitation Smith S, Madzivhandila P, Sewart R, Govender U, Becker H, Roux P, et al. Microfluidic cartridges for automated, point-of-care blood cell counting. 2016; http://hdl.handle.net/10204/9546. en_ZA
dc.identifier.ris TY - Article AU - Smith, Suzanne AU - Madzivhandila, Phophi AU - Sewart, R AU - Govender, Ureshnie AU - Becker, H AU - Roux, Pieter AU - Land, Kevin J AB - Disposable, low-cost microfluidic cartridges for automated blood cell counting applications are presented in this article. The need for point-of-care medical diagnostic tools is evident, particularly in low-resource and rural settings, and a full blood count is often the first step in patient diagnosis. Total white and red blood cell counts have been implemented toward a full blood count, using microfluidic cartridges with automated sample introduction and processing steps for visual microscopy cell counting to be performed. The functional steps within the microfluidic cartridge as well as the surrounding instrumentation required to control and test the cartridges in an automated fashion are described. The results recorded from 10 white blood cell and 10 red blood cell counting cartridges are presented and compare well with the results obtained from the accepted gold-standard flow cytometry method performed at pathology laboratories. Comparisons were also made using manual methods of blood cell counting using a hemocytometer, as well as a commercially available point-of-care white blood cell counting system. The functionality of the blood cell counting microfluidic cartridges can be extended to platelet counting and potential hemoglobin analysis, toward the implementation of an automated, point-of-care full blood count. DA - 2016-11 DB - ResearchSpace DP - CSIR KW - Microfluidics KW - Point-of-care diagnostics KW - Blood cell counting LK - https://researchspace.csir.co.za PY - 2016 SM - 2211-0682 T1 - Microfluidic cartridges for automated, point-of-care blood cell counting TI - Microfluidic cartridges for automated, point-of-care blood cell counting UR - http://hdl.handle.net/10204/9546 ER - en_ZA


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