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Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells

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dc.contributor.advisor
dc.contributor.author Manoto, Sello L
dc.contributor.author Oluwole, DO
dc.contributor.author Malabi, Rudzani
dc.contributor.author Maphanga, Charles P
dc.contributor.author Ombinda-Lemboumba, Saturnin
dc.contributor.author Nyokong, T
dc.contributor.author Mthunzi-Kufa, Patience
dc.date.accessioned 2017-07-28T08:58:39Z
dc.date.available 2017-07-28T08:58:39Z
dc.date.issued 2017-02
dc.identifier.citation Manoto, S.L., Oluwole, D., Malabi, R., Maphanga, C.P., Ombinda-Lemboumba, S., Nyokong, T. & Mthunzi-Kufa, P. 2017. Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells. SPIE. http://hdl.handle.net/10204/9304 . en_ZA
dc.identifier.uri doi:10.1117/12.2252838
dc.identifier.uri http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2603305
dc.identifier.uri http://hdl.handle.net/10204/9304
dc.description Copyright: 2017 SPIE. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. en_US
dc.description.abstract Photodynamic therapy (PDT) is a minimally invasive therapeutic modality for the treatment of neoplastic and non-neoplastic diseases. In PDT of cancer, irradiation with light of a specific wavelength leads to activation of a photosensitizer, which results in generation of reactive oxygen species (ROS) which induces cell death. Many phthalocyanine photosensitizers are hydrophobic and insoluble in water, which limits their therapeutic efficiency. Consequently, advanced delivery systems and strategies are needed to improve the effectiveness of these photosensitizers. Nanoparticles have shown promising results in increasing aqueous solubility, bioavailability, stability and delivery of photosensitizers to their target. This study investigated the photodynamic activity of zinc monocarboxyphenoxy phthalocyanine (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells. The photodynamic activity of ZnMCPPc conjugated to AuAg nanoparticles were evaluated using cellular morphology, viability, proliferation and cytotoxicity. Untreated cells showed no changes in cellular morphology, proliferation and cytotoxicity. However, photoactivated ZnMCPPc conjugated to AuAg nanoparticles showed changes in cell morphology and a dose dependent decrease in cellular viability, proliferation and an increase in cell membrane damage. The ZnMCPPc conjugated to AuAg nanoparticles used in this study was highly effective in inducing cell death of melanoma cancer cells. en_US
dc.language.iso en en_US
dc.publisher SPIE en_US
dc.relation.ispartofseries Worklist;18641
dc.subject Photodynamic therapy en_US
dc.subject Gold silver nanoparticles en_US
dc.subject Zinc monocarboxyphenoxy phthalocyanine en_US
dc.subject Melanoma cancer en_US
dc.title Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells
dc.type Conference Presentation en_US
dc.identifier.apacitation Manoto, S. L., Oluwole, D., Malabi, R., Maphanga, C. P., Ombinda-Lemboumba, S., Nyokong, T., & Mthunzi-Kufa, P. (2017). Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells. SPIE. http://hdl.handle.net/10204/9304 en_ZA
dc.identifier.chicagocitation Manoto, Sello L, DO Oluwole, Rudzani Malabi, Charles P Maphanga, Saturnin Ombinda-Lemboumba, T Nyokong, and Patience Mthunzi-Kufa. "Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells." (2017): http://hdl.handle.net/10204/9304 en_ZA
dc.identifier.vancouvercitation Manoto SL, Oluwole D, Malabi R, Maphanga CP, Ombinda-Lemboumba S, Nyokong T, et al, Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells; SPIE; 2017. http://hdl.handle.net/10204/9304 . en_ZA
dc.identifier.ris TY - Conference Presentation AU - Manoto, Sello L AU - Oluwole, DO AU - Malabi, Rudzani AU - Maphanga, Charles P AU - Ombinda-Lemboumba, Saturnin AU - Nyokong, T AU - Mthunzi-Kufa, Patience AB - Photodynamic therapy (PDT) is a minimally invasive therapeutic modality for the treatment of neoplastic and non-neoplastic diseases. In PDT of cancer, irradiation with light of a specific wavelength leads to activation of a photosensitizer, which results in generation of reactive oxygen species (ROS) which induces cell death. Many phthalocyanine photosensitizers are hydrophobic and insoluble in water, which limits their therapeutic efficiency. Consequently, advanced delivery systems and strategies are needed to improve the effectiveness of these photosensitizers. Nanoparticles have shown promising results in increasing aqueous solubility, bioavailability, stability and delivery of photosensitizers to their target. This study investigated the photodynamic activity of zinc monocarboxyphenoxy phthalocyanine (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells. The photodynamic activity of ZnMCPPc conjugated to AuAg nanoparticles were evaluated using cellular morphology, viability, proliferation and cytotoxicity. Untreated cells showed no changes in cellular morphology, proliferation and cytotoxicity. However, photoactivated ZnMCPPc conjugated to AuAg nanoparticles showed changes in cell morphology and a dose dependent decrease in cellular viability, proliferation and an increase in cell membrane damage. The ZnMCPPc conjugated to AuAg nanoparticles used in this study was highly effective in inducing cell death of melanoma cancer cells. DA - 2017-02 DB - ResearchSpace DP - CSIR KW - Photodynamic therapy KW - Gold silver nanoparticles KW - Zinc monocarboxyphenoxy phthalocyanine KW - Melanoma cancer LK - https://researchspace.csir.co.za PY - 2017 UR - http://hdl.handle.net/10204/9304 ER - en_ZA


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