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Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

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dc.contributor.author Panayides, Jenny-Lee
dc.contributor.author Mathieu, V
dc.contributor.author Banuls, LMY
dc.contributor.author Apostolellis, H
dc.contributor.author Dahan-Farkas, N
dc.contributor.author Davids, H
dc.contributor.author Harmse, L
dc.contributor.author Rey, MEC
dc.contributor.author Green, IR
dc.contributor.author Pelly, SC
dc.contributor.author Kiss, R
dc.contributor.author Kornienko, A
dc.contributor.author Van Otterlo, WAL
dc.date.accessioned 2016-09-08T09:22:49Z
dc.date.available 2016-09-08T09:22:49Z
dc.date.issued 2016-06
dc.identifier.citation Panayides, J-L. Mathieu, V. Banuls, L.M.Y. Apostolellis, H. Dahan-Farkas, N. Davids, H. Harmse, L. Rey, M.E.C. Green, I.R. Pelly, S.C. Kiss, R. Kornienko, A. and Van Otterlo, W.A.L. 2016. Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. Bioorganic & Medicinal Chemistry, 24(16), 2716-2724 en_US
dc.identifier.issn 0968-0896
dc.identifier.uri http://hdl.handle.net/10204/8768
dc.description Copyright: 2015 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Bioorganic & Medicinal Chemistry, 24(16), 2716-2724 en_US
dc.description.abstract Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentration of 100 µM against a small panel of tumor cell lines (HL-60, K-562, Jurkat, Caco-2 and HT-29). The entire set was also tested at varying concentrations against two human glioma lines (U373 and Hs683) to obtain GI(sub50) values, with the best results being values of 25 µM. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Workflow;17265
dc.subject Nucleosides en_US
dc.subject Silyl protecting groups en_US
dc.subject Antiproliferative activities en_US
dc.subject tert-Butyldimethylsilyl en_US
dc.subject Dimethoxytrityl en_US
dc.subject 1,3-Dihydroxy-1,1,3,3- tetraisopropyldisiloxane en_US
dc.title Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides en_US
dc.type Article en_US
dc.identifier.apacitation Panayides, J., Mathieu, V., Banuls, L., Apostolellis, H., Dahan-Farkas, N., Davids, H., ... Van Otterlo, W. (2016). Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. http://hdl.handle.net/10204/8768 en_ZA
dc.identifier.chicagocitation Panayides, Jenny-Lee, V Mathieu, LMY Banuls, H Apostolellis, N Dahan-Farkas, H Davids, L Harmse, et al "Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides." (2016) http://hdl.handle.net/10204/8768 en_ZA
dc.identifier.vancouvercitation Panayides J, Mathieu V, Banuls L, Apostolellis H, Dahan-Farkas N, Davids H, et al. Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides. 2016; http://hdl.handle.net/10204/8768. en_ZA
dc.identifier.ris TY - Article AU - Panayides, Jenny-Lee AU - Mathieu, V AU - Banuls, LMY AU - Apostolellis, H AU - Dahan-Farkas, N AU - Davids, H AU - Harmse, L AU - Rey, MEC AU - Green, IR AU - Pelly, SC AU - Kiss, R AU - Kornienko, A AU - Van Otterlo, WAL AB - Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentration of 100 µM against a small panel of tumor cell lines (HL-60, K-562, Jurkat, Caco-2 and HT-29). The entire set was also tested at varying concentrations against two human glioma lines (U373 and Hs683) to obtain GI(sub50) values, with the best results being values of 25 µM. DA - 2016-06 DB - ResearchSpace DP - CSIR KW - Nucleosides KW - Silyl protecting groups KW - Antiproliferative activities KW - tert-Butyldimethylsilyl KW - Dimethoxytrityl KW - 1,3-Dihydroxy-1,1,3,3- tetraisopropyldisiloxane LK - https://researchspace.csir.co.za PY - 2016 SM - 0968-0896 T1 - Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides TI - Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides UR - http://hdl.handle.net/10204/8768 ER - en_ZA


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