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CD-based microfluidics for primary care in extreme point-of-care settings

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dc.contributor.author Smith, S
dc.contributor.author Mager, D
dc.contributor.author Perebikovsky, A
dc.contributor.author Shamloo, E
dc.contributor.author Kinahan, D
dc.contributor.author Mishra, D
dc.contributor.author Delgado, SMT
dc.contributor.author Kido, H
dc.contributor.author Saha, S
dc.contributor.author Ducrée, J
dc.contributor.author Madou, M
dc.contributor.author Land, K
dc.contributor.author Korvink, JG
dc.date.accessioned 2016-05-16T10:13:25Z
dc.date.available 2016-05-16T10:13:25Z
dc.date.issued 2016-01
dc.identifier.citation Smith, S. Mager, D. Perebikovsky, A. Shamloo, E. Kinahan, D. Mishra, D. Delgado, S.M.T. Kido, H. Saha, S. Ducrée, J. Madou, M. Land, K. and Korvink, J.G. (2016) CD-based microfluidics for primary care in extreme point-of-care settings. Micromachines, 7(2), 1-22 en_US
dc.identifier.issn 2072-666X
dc.identifier.uri http://www.mdpi.com/2072-666X/7/2/22
dc.identifier.uri http://hdl.handle.net/10204/8532
dc.description Copyright: 2015 MDPI en_US
dc.description.abstract We review the utility of centrifugal microfluidic technologies applied to point-of-care diagnosis in extremely under-resourced environments. The various challenges faced in these settings are showcased, using areas in India and Africa as examples. Measures for the ability of integrated devices to effectively address point-of-care challenges are highlighted, and centrifugal, often termed CD-based microfluidic technologies, technologies are presented as a promising platform to address these challenges. We describe the advantages of centrifugal liquid handling, as well as the ability of a standard CD player to perform a number of common laboratory tests, fulfilling the role of an integrated lab-on-a-CD. Innovative centrifugal approaches for point-of-care in extremely resource-poor settings are highlighted, including sensing and detection strategies, smart power sources and biomimetic inspiration for environmental control. The evolution of centrifugal microfluidics, along with examples of commercial and advanced prototype centrifugal microfluidic systems, is presented, illustrating the success of deployment at the point-of-care. A close fit of emerging centrifugal systems to address a critical panel of tests for under-resourced clinic settings, formulated by medical experts, is demonstrated. This emphasizes the potential of centrifugal microfluidic technologies to be applied effectively to extremely challenging point-of-care scenarios and in playing a role in improving primary care in resource-limited settings across the developing world. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Workflow;16323
dc.subject Primary care en_US
dc.subject Extreme point-of-care en_US
dc.subject Centrifugal microfluidics en_US
dc.subject Lab-on-a-disc en_US
dc.title CD-based microfluidics for primary care in extreme point-of-care settings en_US
dc.type Article en_US
dc.identifier.apacitation Smith, S., Mager, D., Perebikovsky, A., Shamloo, E., Kinahan, D., Mishra, D., ... Korvink, J. (2016). CD-based microfluidics for primary care in extreme point-of-care settings. http://hdl.handle.net/10204/8532 en_ZA
dc.identifier.chicagocitation Smith, S, D Mager, A Perebikovsky, E Shamloo, D Kinahan, D Mishra, SMT Delgado, et al "CD-based microfluidics for primary care in extreme point-of-care settings." (2016) http://hdl.handle.net/10204/8532 en_ZA
dc.identifier.vancouvercitation Smith S, Mager D, Perebikovsky A, Shamloo E, Kinahan D, Mishra D, et al. CD-based microfluidics for primary care in extreme point-of-care settings. 2016; http://hdl.handle.net/10204/8532. en_ZA
dc.identifier.ris TY - Article AU - Smith, S AU - Mager, D AU - Perebikovsky, A AU - Shamloo, E AU - Kinahan, D AU - Mishra, D AU - Delgado, SMT AU - Kido, H AU - Saha, S AU - Ducrée, J AU - Madou, M AU - Land, K AU - Korvink, JG AB - We review the utility of centrifugal microfluidic technologies applied to point-of-care diagnosis in extremely under-resourced environments. The various challenges faced in these settings are showcased, using areas in India and Africa as examples. Measures for the ability of integrated devices to effectively address point-of-care challenges are highlighted, and centrifugal, often termed CD-based microfluidic technologies, technologies are presented as a promising platform to address these challenges. We describe the advantages of centrifugal liquid handling, as well as the ability of a standard CD player to perform a number of common laboratory tests, fulfilling the role of an integrated lab-on-a-CD. Innovative centrifugal approaches for point-of-care in extremely resource-poor settings are highlighted, including sensing and detection strategies, smart power sources and biomimetic inspiration for environmental control. The evolution of centrifugal microfluidics, along with examples of commercial and advanced prototype centrifugal microfluidic systems, is presented, illustrating the success of deployment at the point-of-care. A close fit of emerging centrifugal systems to address a critical panel of tests for under-resourced clinic settings, formulated by medical experts, is demonstrated. This emphasizes the potential of centrifugal microfluidic technologies to be applied effectively to extremely challenging point-of-care scenarios and in playing a role in improving primary care in resource-limited settings across the developing world. DA - 2016-01 DB - ResearchSpace DP - CSIR KW - Primary care KW - Extreme point-of-care KW - Centrifugal microfluidics KW - Lab-on-a-disc LK - https://researchspace.csir.co.za PY - 2016 SM - 2072-666X T1 - CD-based microfluidics for primary care in extreme point-of-care settings TI - CD-based microfluidics for primary care in extreme point-of-care settings UR - http://hdl.handle.net/10204/8532 ER - en_ZA


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