dc.contributor.author |
Van der Westhuyzen, Christiaan W
|
|
dc.contributor.author |
Parkinson, CJ
|
|
dc.date.accessioned |
2007-06-29T08:00:26Z |
|
dc.date.available |
2007-06-29T08:00:26Z |
|
dc.date.issued |
2005 |
|
dc.identifier.citation |
Van der Westhuyzen, CW and Parkinson, CJ. 2005. Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. South African Journal of Chemistry, vol. 58, pp 41-45 |
en |
dc.identifier.issn |
0379-4350 |
|
dc.identifier.uri |
http://hdl.handle.net/10204/763
|
|
dc.description |
Copyright: 2005 Bureau Scientific Publications |
en |
dc.description.abstract |
Alpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity. |
en |
dc.language.iso |
en |
en |
dc.publisher |
Bureau Scientific Publications |
en |
dc.subject |
Singlet oxygen |
en |
dc.subject |
Santonin |
en |
dc.subject |
Photo-oxygenated |
en |
dc.subject |
Endoperoxide |
en |
dc.title |
Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin |
en |
dc.type |
Article |
en |
dc.identifier.apacitation |
Van der Westhuyzen, C. W., & Parkinson, C. (2005). Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. http://hdl.handle.net/10204/763 |
en_ZA |
dc.identifier.chicagocitation |
Van der Westhuyzen, Christiaan W, and CJ Parkinson "Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin." (2005) http://hdl.handle.net/10204/763 |
en_ZA |
dc.identifier.vancouvercitation |
Van der Westhuyzen CW, Parkinson C. Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. 2005; http://hdl.handle.net/10204/763. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Van der Westhuyzen, Christiaan W
AU - Parkinson, CJ
AB - Alpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity.
DA - 2005
DB - ResearchSpace
DP - CSIR
KW - Singlet oxygen
KW - Santonin
KW - Photo-oxygenated
KW - Endoperoxide
LK - https://researchspace.csir.co.za
PY - 2005
SM - 0379-4350
T1 - Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin
TI - Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin
UR - http://hdl.handle.net/10204/763
ER -
|
en_ZA |