dc.contributor.author |
Hata, Y
|
|
dc.contributor.author |
Ebrahimi, SN
|
|
dc.contributor.author |
De Mieri, M
|
|
dc.contributor.author |
Zimmermann, S
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|
dc.contributor.author |
Mokoka, T
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|
dc.contributor.author |
Naidoo, Dashnie
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|
dc.contributor.author |
Fouché, Gerda
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|
dc.contributor.author |
Maharaj
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|
dc.contributor.author |
Kaiser, M
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|
dc.contributor.author |
Brun, R
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|
dc.contributor.author |
Potterat, O
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|
dc.contributor.author |
Hamburger, M
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|
dc.date.accessioned |
2014-06-17T09:56:26Z |
|
dc.date.available |
2014-06-17T09:56:26Z |
|
dc.date.issued |
2014-03 |
|
dc.identifier.citation |
Hata, Y, Ebrahimi, S.N, De Mieri, M, Zimmermann, S, Mokoka, T, Naidoo, D, Fouche, G, Maharaj, V, Kaiser, M, Brun, R, Potterat, O and Hamburger, M. 2014. Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, vol. 93, pp 81-87 |
en_US |
dc.identifier.issn |
0367-326X |
|
dc.identifier.uri |
http://ac.els-cdn.com/S0367326X13003249/1-s2.0-S0367326X13003249-main.pdf?_tid=2758918c-f16d-11e3-ba48-00000aab0f02&acdnat=1402493866_dee86fd3c158a9fe39f95a00211baa3d
|
|
dc.identifier.uri |
http://hdl.handle.net/10204/7445
|
|
dc.description |
Copyright: 2014 Elsevier. This is an ABSTRACT ONLY. The definitive version is published in Fitoterapia, vol. 93, pp 81-87 |
en_US |
dc.description.abstract |
Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus precatorius as potent in vitro trypanocidal compounds with high selectivity indices. To obtain sufficient compound for in vivo efficacy tests in mice, a second batch of plant material was re-collected and extracted. However, the chemical profiles of the two batches differed, and additional abruquinoneswere isolated and identified by HR-ESI-MS, and 1D and 2D NMR (sup1)H, (sup13)C, COSY, HMBC, HSQC, and NOESY) spectroscopy. Abruquinones J (1), K (2), and L (3)were new,while abruquinones A (4) and D (5)were known from the first batch of plant material. The absolute configuration of compounds 1 to 3was determined by comparison of electronic circular dichroism (ECD) spectra with calculated ECD data. Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC(sub50) of 0.01, 0.02, 0.02 and 0.01 µM, respectively), and remarkable SIs of 508, 374, 1379, and 668, respectively. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.relation.ispartofseries |
Workflow;12824 |
|
dc.subject |
Trypanosoma brucei rhodesiense |
en_US |
dc.subject |
Isoflavan quinone |
en_US |
dc.subject |
Abrus precatorius |
en_US |
dc.subject |
Fabaceae |
en_US |
dc.subject |
Human African trypanosomiasis |
en_US |
dc.subject |
HAT |
en_US |
dc.title |
Antitrypanosomal isoflavan quinones from Abrus precatorius |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Hata, Y., Ebrahimi, S., De Mieri, M., Zimmermann, S., Mokoka, T., Naidoo, D., ... Hamburger, M. (2014). Antitrypanosomal isoflavan quinones from Abrus precatorius. http://hdl.handle.net/10204/7445 |
en_ZA |
dc.identifier.chicagocitation |
Hata, Y, SN Ebrahimi, M De Mieri, S Zimmermann, T Mokoka, Dashnie Naidoo, Gerda Fouché, et al "Antitrypanosomal isoflavan quinones from Abrus precatorius." (2014) http://hdl.handle.net/10204/7445 |
en_ZA |
dc.identifier.vancouvercitation |
Hata Y, Ebrahimi S, De Mieri M, Zimmermann S, Mokoka T, Naidoo D, et al. Antitrypanosomal isoflavan quinones from Abrus precatorius. 2014; http://hdl.handle.net/10204/7445. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Hata, Y
AU - Ebrahimi, SN
AU - De Mieri, M
AU - Zimmermann, S
AU - Mokoka, T
AU - Naidoo, Dashnie
AU - Fouché, Gerda
AU - Maharaj
AU - Kaiser, M
AU - Brun, R
AU - Potterat, O
AU - Hamburger, M
AB - Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus precatorius as potent in vitro trypanocidal compounds with high selectivity indices. To obtain sufficient compound for in vivo efficacy tests in mice, a second batch of plant material was re-collected and extracted. However, the chemical profiles of the two batches differed, and additional abruquinoneswere isolated and identified by HR-ESI-MS, and 1D and 2D NMR (sup1)H, (sup13)C, COSY, HMBC, HSQC, and NOESY) spectroscopy. Abruquinones J (1), K (2), and L (3)were new,while abruquinones A (4) and D (5)were known from the first batch of plant material. The absolute configuration of compounds 1 to 3was determined by comparison of electronic circular dichroism (ECD) spectra with calculated ECD data. Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC(sub50) of 0.01, 0.02, 0.02 and 0.01 µM, respectively), and remarkable SIs of 508, 374, 1379, and 668, respectively.
DA - 2014-03
DB - ResearchSpace
DP - CSIR
KW - Trypanosoma brucei rhodesiense
KW - Isoflavan quinone
KW - Abrus precatorius
KW - Fabaceae
KW - Human African trypanosomiasis
KW - HAT
LK - https://researchspace.csir.co.za
PY - 2014
SM - 0367-326X
T1 - Antitrypanosomal isoflavan quinones from Abrus precatorius
TI - Antitrypanosomal isoflavan quinones from Abrus precatorius
UR - http://hdl.handle.net/10204/7445
ER -
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en_ZA |