dc.contributor.author |
Adewusi, EA
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dc.contributor.author |
Fouché, Gerda
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dc.contributor.author |
Steenkamp, V
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dc.date.accessioned |
2013-06-12T12:44:30Z |
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dc.date.available |
2013-06-12T12:44:30Z |
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dc.date.issued |
2013 |
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dc.identifier.citation |
Adewusi, E.A, Fouche, G and Steenkamp, V. 2012. Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells. African Journal of Traditional Complementary Alternative Medicine, vol. 10(4) |
en_US |
dc.identifier.uri |
http://journals.sfu.ca/africanem/index.php/ajtcam/article/viewArticle/1829
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dc.identifier.uri |
http://hdl.handle.net/10204/6779
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dc.description |
Copyright: 2013. AJTCAM. This an ABSTRACT ONLY. The definitive version is published in African Journal of Traditional Complementary Alternative Medicine, vol. 10(4) |
en_US |
dc.description.abstract |
Amyloid-beta peptide (Aß) is implicated in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder. This study was designed to determine the effect of four medicinal plants used to treat neurodegenerative diseases on Aß-induced cell death. Cytotoxicity of the ethanol extracts of the plants was determined against SH-SY5Y (human neuroblastoma) cells which were untreated, as well as toxically induced with Aß, using the MTT and neutral red uptake assays. Cell viability was reduced to 16% when exposed to 20 µM Aß25-35 for 72 h. The methanol extract of the roots of Ziziphus mucronata Willd., Lannea schweinfurthii (Engl.) Engl. and Terminalia sericea Burch. ex DC., were the least toxic to the SH-SY5Ycells at the highest concentration tested (100 µg/ml). All four plants tested were observed to reduce the effects of Aß-induced neuronal cell death, indicating that they may contain compounds which may be relevant in the prevention of AD progression. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
African Journal of Traditional Complementary Alternative Medicine |
en_US |
dc.relation.ispartofseries |
Workflow;11099 |
|
dc.subject |
Amyloid-beta peptides |
en_US |
dc.subject |
Alzheimer’s disease |
en_US |
dc.subject |
Neurodegenerative disorders |
en_US |
dc.subject |
Medicinal plants |
en_US |
dc.title |
Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Adewusi, E., Fouché, G., & Steenkamp, V. (2013). Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells. http://hdl.handle.net/10204/6779 |
en_ZA |
dc.identifier.chicagocitation |
Adewusi, EA, Gerda Fouché, and V Steenkamp "Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells." (2013) http://hdl.handle.net/10204/6779 |
en_ZA |
dc.identifier.vancouvercitation |
Adewusi E, Fouché G, Steenkamp V. Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells. 2013; http://hdl.handle.net/10204/6779. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Adewusi, EA
AU - Fouché, Gerda
AU - Steenkamp, V
AB - Amyloid-beta peptide (Aß) is implicated in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder. This study was designed to determine the effect of four medicinal plants used to treat neurodegenerative diseases on Aß-induced cell death. Cytotoxicity of the ethanol extracts of the plants was determined against SH-SY5Y (human neuroblastoma) cells which were untreated, as well as toxically induced with Aß, using the MTT and neutral red uptake assays. Cell viability was reduced to 16% when exposed to 20 µM Aß25-35 for 72 h. The methanol extract of the roots of Ziziphus mucronata Willd., Lannea schweinfurthii (Engl.) Engl. and Terminalia sericea Burch. ex DC., were the least toxic to the SH-SY5Ycells at the highest concentration tested (100 µg/ml). All four plants tested were observed to reduce the effects of Aß-induced neuronal cell death, indicating that they may contain compounds which may be relevant in the prevention of AD progression.
DA - 2013
DB - ResearchSpace
DP - CSIR
KW - Amyloid-beta peptides
KW - Alzheimer’s disease
KW - Neurodegenerative disorders
KW - Medicinal plants
LK - https://researchspace.csir.co.za
PY - 2013
T1 - Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells
TI - Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells
UR - http://hdl.handle.net/10204/6779
ER -
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en_ZA |