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Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)
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| dc.contributor.author |
Adekanmi, AE
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| dc.contributor.author |
Fouché, Gerda
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| dc.contributor.author |
Steenkamp, V
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| dc.date.accessioned | 2012-11-27T07:45:54Z | |
| dc.date.available | 2012-11-27T07:45:54Z | |
| dc.date.issued | 2012-09 | |
| dc.identifier.citation | Adekanmi, AE, Fouche, G and Steenkamp, V. 2012. Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae). Journal of Ethnopharmacology, vol. 143(2), pp 572-578 | en_US |
| dc.identifier.issn | 0378-8741 | |
| dc.identifier.issn | 1872-7573 | |
| dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0378874112004801 | |
| dc.identifier.uri | http://hdl.handle.net/10204/6381 | |
| dc.description | Copyright: 2012 Elsevier. All rights reserved. This is the author’s version of the work. The definitive version is published in Journal of Ethnopharmacology, vol 143, issue 2, September 2012, pp 572-578, doi:10.1016/j.jep.2012.07.011. | en_US |
| dc.description.abstract | Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. Weak decoctions of bulb scales are given to sedate violent, psychotic patients while bulb infusions are reported to be used to treat mental illness. The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of Boophane disticha. Although this compound possessed activity, it was found to be toxic to the neuroblastoma cells. Quantitative structure-activity relationship studies could be carried out to modify the structure in order to make it less toxic and improve its activity. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | Workflow;9241 | |
| dc.subject | Acetylcholinesterase | en_US |
| dc.subject | Amaryllidaceae | en_US |
| dc.subject | Boophane disticha | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.subject | SH-SY5Y cells | en_US |
| dc.subject | 6-hydroxycrinamine | en_US |
| dc.title | Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae) | en_US |
| dc.type | Article | en_US |
| dc.identifier.apacitation | Adekanmi, A., Fouché, G., & Steenkamp, V. (2012). Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae). http://hdl.handle.net/10204/6381 | en_ZA |
| dc.identifier.chicagocitation | Adekanmi, AE, Gerda Fouché, and V Steenkamp "Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)." (2012) http://hdl.handle.net/10204/6381 | en_ZA |
| dc.identifier.vancouvercitation | Adekanmi A, Fouché G, Steenkamp V. Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae). 2012; http://hdl.handle.net/10204/6381. | en_ZA |
| dc.identifier.ris | TY - Article AU - Adekanmi, AE AU - Fouché, Gerda AU - Steenkamp, V AB - Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. Weak decoctions of bulb scales are given to sedate violent, psychotic patients while bulb infusions are reported to be used to treat mental illness. The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of Boophane disticha. Although this compound possessed activity, it was found to be toxic to the neuroblastoma cells. Quantitative structure-activity relationship studies could be carried out to modify the structure in order to make it less toxic and improve its activity. DA - 2012-09 DB - ResearchSpace DP - CSIR KW - Acetylcholinesterase KW - Amaryllidaceae KW - Boophane disticha KW - Cytotoxicity KW - SH-SY5Y cells KW - 6-hydroxycrinamine LK - https://researchspace.csir.co.za PY - 2012 SM - 0378-8741 SM - 1872-7573 T1 - Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae) TI - Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae) UR - http://hdl.handle.net/10204/6381 ER - | en_ZA |
