dc.contributor.author |
London, GG
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|
dc.contributor.author |
Madiga, MM
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|
dc.contributor.author |
Gray, EE
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|
dc.contributor.author |
Sok, DD
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|
dc.contributor.author |
Morris, LL
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dc.contributor.author |
Burton, DD
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dc.contributor.author |
Khati, MM
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|
dc.date.accessioned |
2012-11-14T08:34:52Z |
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dc.date.available |
2012-11-14T08:34:52Z |
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dc.date.issued |
2012-09 |
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dc.identifier.citation |
London, GG, Madiga, MM, Gray, EE, Sok, DD, Morris, LL, Burton, DD and Khati, MM. 2012. Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. Retrovirology, vol. 9 (supplement 2), p. 222 |
en_US |
dc.identifier.issn |
1742-4690 |
|
dc.identifier.uri |
http://www.retrovirology.com/content/pdf/1742-4690-9-S2-P222.pdf
|
|
dc.identifier.uri |
http://hdl.handle.net/10204/6313
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|
dc.description |
Copyright: 2012 London et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
en_US |
dc.description.abstract |
Human immunodeficiency virus type-I (HIV-1) envelope glycoprotein (Env) mediates the first step of entry and represents an attractive target . However, the genetic diversity of Env among HIV-1 subtypes poses a challenge. Although evidence suggest that entry inhibitors in clinical use have comparable efficacy against HIV-1 subtypes, but a subset of anti-Env are resistant to HIV-1 subtype C which is the most globally prevalent virus. In a view to prevent infection of HIV-1 subtype C, we isolated nucleic acids ligands aptamers against HIV-1 subtype C Env pseudovirion and tested their efficacy. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
BioMed Central |
en_US |
dc.relation.ispartofseries |
Workflow;9653 |
|
dc.subject |
Human immunodeficiency virus type-I |
en_US |
dc.subject |
Virology |
en_US |
dc.subject |
HIV-1 subtype C |
en_US |
dc.subject |
2'F-RNA Aptamers |
en_US |
dc.subject |
Envelope pseudovirus |
en_US |
dc.title |
Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
London, G., Madiga, M., Gray, E., Sok, D., Morris, L., Burton, D., & Khati, M. (2012). Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. http://hdl.handle.net/10204/6313 |
en_ZA |
dc.identifier.chicagocitation |
London, GG, MM Madiga, EE Gray, DD Sok, LL Morris, DD Burton, and MM Khati "Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus." (2012) http://hdl.handle.net/10204/6313 |
en_ZA |
dc.identifier.vancouvercitation |
London G, Madiga M, Gray E, Sok D, Morris L, Burton D, et al. Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus. 2012; http://hdl.handle.net/10204/6313. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - London, GG
AU - Madiga, MM
AU - Gray, EE
AU - Sok, DD
AU - Morris, LL
AU - Burton, DD
AU - Khati, MM
AB - Human immunodeficiency virus type-I (HIV-1) envelope glycoprotein (Env) mediates the first step of entry and represents an attractive target . However, the genetic diversity of Env among HIV-1 subtypes poses a challenge. Although evidence suggest that entry inhibitors in clinical use have comparable efficacy against HIV-1 subtypes, but a subset of anti-Env are resistant to HIV-1 subtype C which is the most globally prevalent virus. In a view to prevent infection of HIV-1 subtype C, we isolated nucleic acids ligands aptamers against HIV-1 subtype C Env pseudovirion and tested their efficacy.
DA - 2012-09
DB - ResearchSpace
DP - CSIR
KW - Human immunodeficiency virus type-I
KW - Virology
KW - HIV-1 subtype C
KW - 2'F-RNA Aptamers
KW - Envelope pseudovirus
LK - https://researchspace.csir.co.za
PY - 2012
SM - 1742-4690
T1 - Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus
TI - Inhibition of HIV-1 subtype C by 2’F-RNA aptamers isolated against enveloped pseudovirus
UR - http://hdl.handle.net/10204/6313
ER -
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en_ZA |