dc.contributor.author |
Pillay, V
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|
dc.contributor.author |
Mashingaidze, F
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|
dc.contributor.author |
Choonara, YE
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|
dc.contributor.author |
Du Toit, LC
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|
dc.contributor.author |
Buckmann, E
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|
dc.contributor.author |
Maharaj, V
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dc.contributor.author |
Ndesendo, VMK
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dc.contributor.author |
Kumar, P
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|
dc.date.accessioned |
2012-06-14T10:07:55Z |
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dc.date.available |
2012-06-14T10:07:55Z |
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dc.date.issued |
2012-06 |
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dc.identifier.citation |
Pillay, V, Mashingaidze, F, Choonara, YE, Du Toit, LC, Buckmann, E, Maharaj, V, Ndesendo, VMK and Kumar, P. 2012. Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. Journal of Pharmaceutical Sciences, vol. 101(6), pp 1950-1968 |
en_US |
dc.identifier.issn |
0022-3549 |
|
dc.identifier.uri |
http://onlinelibrary.wiley.com/doi/10.1002/jps.23098/abstract
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|
dc.identifier.uri |
http://onlinelibrary.wiley.com/doi/10.1002/jps.23098/pdf
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|
dc.identifier.uri |
http://hdl.handle.net/10204/5906
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|
dc.description |
Copyright: 2012 Wiley Periodicals, Inc. and the American Pharmacists Association. This is an ABSTRACT ONLY. |
en_US |
dc.description.abstract |
The past decade has seen several effective anti-HIV-1 agent discoveries, yet microbicides continue to disappoint clinically. Our review expounds the view that unsatisfactory microbicide failures may be a result of inefficient delivery systems employed. We hereby propose a thorough scientific qualitative and quantitative investigation of important aspects involved in HIV-1 transmission as a prerequisite for microbicide delivery. Intravaginal targeting of HIV-1 increases the chances of microbicide success, wherein vaginal microenvironmental factors including pH should be maintained at HIV-1 prohibitive acidic levels simultaneously to ward off other sexually transmitted diseases, which compromise vaginal epithelial barrier properties. Furthermore, choice of receptors to target both on HIV-1 and on target cells is vital in deterring transmission. Appropriate modeling of virus–target cell interactions as well as targeting early stages of the HIV-1 infection accompanied by computation and delivery of appropriate microbicide quantities could revolutionize microbicide research, ultimately delivering a female-controlled HIV-1 prevention modality appropriately. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.relation.ispartofseries |
Workflow;8927 |
|
dc.subject |
Targeted drug delivery |
en_US |
dc.subject |
Special populations |
en_US |
dc.subject |
Site-specific delivery |
en_US |
dc.subject |
Polymeric drug delivery systems |
en_US |
dc.subject |
Polymer–biopolymer interactions |
en_US |
dc.subject |
Physicochemical properties |
en_US |
dc.subject |
Pharmacokinetics |
en_US |
dc.subject |
Pharmacodynamics |
en_US |
dc.subject |
Permeability |
en_US |
dc.subject |
Mucosal delivery |
en_US |
dc.subject |
Macromolecular drug delivery |
en_US |
dc.title |
Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Pillay, V., Mashingaidze, F., Choonara, Y., Du Toit, L., Buckmann, E., Maharaj, V., ... Kumar, P. (2012). Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. http://hdl.handle.net/10204/5906 |
en_ZA |
dc.identifier.chicagocitation |
Pillay, V, F Mashingaidze, YE Choonara, LC Du Toit, E Buckmann, V Maharaj, VMK Ndesendo, and P Kumar "Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success." (2012) http://hdl.handle.net/10204/5906 |
en_ZA |
dc.identifier.vancouvercitation |
Pillay V, Mashingaidze F, Choonara Y, Du Toit L, Buckmann E, Maharaj V, et al. Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. 2012; http://hdl.handle.net/10204/5906. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Pillay, V
AU - Mashingaidze, F
AU - Choonara, YE
AU - Du Toit, LC
AU - Buckmann, E
AU - Maharaj, V
AU - Ndesendo, VMK
AU - Kumar, P
AB - The past decade has seen several effective anti-HIV-1 agent discoveries, yet microbicides continue to disappoint clinically. Our review expounds the view that unsatisfactory microbicide failures may be a result of inefficient delivery systems employed. We hereby propose a thorough scientific qualitative and quantitative investigation of important aspects involved in HIV-1 transmission as a prerequisite for microbicide delivery. Intravaginal targeting of HIV-1 increases the chances of microbicide success, wherein vaginal microenvironmental factors including pH should be maintained at HIV-1 prohibitive acidic levels simultaneously to ward off other sexually transmitted diseases, which compromise vaginal epithelial barrier properties. Furthermore, choice of receptors to target both on HIV-1 and on target cells is vital in deterring transmission. Appropriate modeling of virus–target cell interactions as well as targeting early stages of the HIV-1 infection accompanied by computation and delivery of appropriate microbicide quantities could revolutionize microbicide research, ultimately delivering a female-controlled HIV-1 prevention modality appropriately.
DA - 2012-06
DB - ResearchSpace
DP - CSIR
KW - Targeted drug delivery
KW - Special populations
KW - Site-specific delivery
KW - Polymeric drug delivery systems
KW - Polymer–biopolymer interactions
KW - Physicochemical properties
KW - Pharmacokinetics
KW - Pharmacodynamics
KW - Permeability
KW - Mucosal delivery
KW - Macromolecular drug delivery
LK - https://researchspace.csir.co.za
PY - 2012
SM - 0022-3549
T1 - Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success
TI - Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success
UR - http://hdl.handle.net/10204/5906
ER -
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en_ZA |