In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling
In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling
Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial agents from South African medicinal plants. One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile.
Reference:
Becker, JVW, Van der Merwe, MM, Van Brummelen, AC, Pillay, P, Crampton, BG, Mmutlane, EM, Parkinson, C, Van Heerden, FR, Crouch, NR, Smith, PJ, Mancama, DT and Maharaj, VJ. 2011. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. Malaria Journal, vol. 10, pp 295
Becker, J., Van der Merwe, M., Van Brummelen, A., Pillay, P., Crampton, B., Mmutlane, E., ... Maharaj, V. (2011). In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. http://hdl.handle.net/10204/5662
Becker, JVW, MM Van der Merwe, AC Van Brummelen, P Pillay, BG Crampton, EM Mmutlane, C Parkinson, et al "In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling." (2011) http://hdl.handle.net/10204/5662
Becker J, Van der Merwe M, Van Brummelen A, Pillay P, Crampton B, Mmutlane E, et al. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. 2011; http://hdl.handle.net/10204/5662.
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