dc.contributor.author |
Nombona, N
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|
dc.contributor.author |
Maduray, K
|
|
dc.contributor.author |
Antunes, E
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|
dc.contributor.author |
Karsten, A
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|
dc.contributor.author |
Nyokong, T
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|
dc.date.accessioned |
2012-03-08T08:50:39Z |
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dc.date.available |
2012-03-08T08:50:39Z |
|
dc.date.issued |
2012-02 |
|
dc.identifier.citation |
Nombona, N, Maduray, K, Antunes, E, Karsten, A and Nyokong, T. 2012. Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, vol. 107, pp 35-44 |
en_US |
dc.identifier.issn |
1011-1344 |
|
dc.identifier.uri |
http://www.sciencedirect.com/science/article/pii/S101113441100251X
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|
dc.identifier.uri |
http://hdl.handle.net/10204/5632
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|
dc.description |
Copyright: 2012 Elsevier. This is an ABSTRACT ONLY |
en_US |
dc.description.abstract |
The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm-2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.relation.ispartofseries |
Workflow;8321 |
|
dc.subject |
Phthalocyanine |
en_US |
dc.subject |
Gold nanoparticles |
en_US |
dc.subject |
Liposomes |
en_US |
dc.subject |
Photodynamic therapy |
en_US |
dc.title |
Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Nombona, N., Maduray, K., Antunes, E., Karsten, A., & Nyokong, T. (2012). Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. http://hdl.handle.net/10204/5632 |
en_ZA |
dc.identifier.chicagocitation |
Nombona, N, K Maduray, E Antunes, A Karsten, and T Nyokong "Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy." (2012) http://hdl.handle.net/10204/5632 |
en_ZA |
dc.identifier.vancouvercitation |
Nombona N, Maduray K, Antunes E, Karsten A, Nyokong T. Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. 2012; http://hdl.handle.net/10204/5632. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Nombona, N
AU - Maduray, K
AU - Antunes, E
AU - Karsten, A
AU - Nyokong, T
AB - The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm-2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity.
DA - 2012-02
DB - ResearchSpace
DP - CSIR
KW - Phthalocyanine
KW - Gold nanoparticles
KW - Liposomes
KW - Photodynamic therapy
LK - https://researchspace.csir.co.za
PY - 2012
SM - 1011-1344
T1 - Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
TI - Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
UR - http://hdl.handle.net/10204/5632
ER -
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en_ZA |