This presentation addresses the replacement and repair of bone. There are four types of biomaterials; namely biotoxic, bioinert, bioactive and ioresorbable. The most abundant inorganic mineral in bone is hydroxyapatite, which is a good candidate for synthetic bone. The following problems were addressed in this presentation: 1) Bioceramics are not resorbed by osteoclasts as intended, 2) Osteoblasts are not recruited to deposit new bone, 3) Most bioceramics still macro-structured while natural occurring crystals are nano-structured, 4) Bioceramics’ surface feature for biomineralisation is unclear, and 5) Fundamentals must be explored to facilitate breakthroughs for clinical biointeractive materials with novel physical, chemical & biological functions.
Reference:
Wepener, I, Richter, W and Joubert, A. 2011. Novel nano-calcium phosphate generation to improve cell activity in bone restructuring. South African Cell Death Society Symposium on “Cell Death in Diseases”. Two Oceans Aquarium, Cape Town, South Africa, 10-12 January 2011. pp 14
Wepener, I., Richter, W., & Joubert, A. (2010). Novel nano-calcium phosphate generation to improve cell activity in bone restructuring. http://hdl.handle.net/10204/4878
Wepener, I, W Richter, and A Joubert. "Novel nano-calcium phosphate generation to improve cell activity in bone restructuring." (2010): http://hdl.handle.net/10204/4878
Wepener I, Richter W, Joubert A, Novel nano-calcium phosphate generation to improve cell activity in bone restructuring; 2010. http://hdl.handle.net/10204/4878 .
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