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Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment

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dc.contributor.author Boca, MB
dc.contributor.author Pretorius, E
dc.contributor.author Kgaje, CG
dc.contributor.author Apostolides, Z
dc.date.accessioned 2009-05-11T08:30:42Z
dc.date.available 2009-05-11T08:30:42Z
dc.date.issued 2008-03
dc.identifier.citation Boca, MB, Pretorius, E, Kgaje, CG and Apostolides, Z. 2008. Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment. Journal of Pharmaceutical and Biomedical Analysis, Vol. 46(4), pp 1-13 en
dc.identifier.issn 0731-7085
dc.identifier.uri http://hdl.handle.net/10204/3368
dc.description Author Posting. Copyright Elsevier, 2008. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution en
dc.description.abstract The suitability of micellar electrokinetic chromatography for the simultaneous trace determination of several compounds (sulfamethoxazole, trimethoprim, sulfanilic acid, sulfanilamide, 3,4,5-trimethoxybenzoic acid and nonoxynol-9) was assessed. The mixture was separated within 14 minutes at an applied voltage of 22 kV by using 30 mM phosphate electrolyte, containing 10 mM SDS, adjusted to pH 7.8. Under optimized separation conditions acceptable levels of linearity, precision and accuracy were obtained for all compounds. The method could be used as part of a cleaning validation study when assaying trace levels of co-trimoxazole drug, some of its decomposition products and detergent in the swab samples collected from pharmaceutical manufacturing equipment, after cleaning en
dc.language.iso en en
dc.publisher Elsevier en
dc.subject Micellar electrokinetic chromatography en
dc.subject MEKC en
dc.subject Pharmaceutical manufacturing equipment en
dc.subject Active pharmaceutical ingredients en
dc.subject APIs en
dc.subject Drug residue en
dc.subject Sulfamethoxazole en
dc.subject SMZ en
dc.subject Trimethoprim en
dc.subject TMP en
dc.title Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment en
dc.type Article en
dc.identifier.apacitation Boca, M., Pretorius, E., Kgaje, C., & Apostolides, Z. (2008). Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment. http://hdl.handle.net/10204/3368 en_ZA
dc.identifier.chicagocitation Boca, MB, E Pretorius, CG Kgaje, and Z Apostolides "Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment." (2008) http://hdl.handle.net/10204/3368 en_ZA
dc.identifier.vancouvercitation Boca M, Pretorius E, Kgaje C, Apostolides Z. Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment. 2008; http://hdl.handle.net/10204/3368. en_ZA
dc.identifier.ris TY - Article AU - Boca, MB AU - Pretorius, E AU - Kgaje, CG AU - Apostolides, Z AB - The suitability of micellar electrokinetic chromatography for the simultaneous trace determination of several compounds (sulfamethoxazole, trimethoprim, sulfanilic acid, sulfanilamide, 3,4,5-trimethoxybenzoic acid and nonoxynol-9) was assessed. The mixture was separated within 14 minutes at an applied voltage of 22 kV by using 30 mM phosphate electrolyte, containing 10 mM SDS, adjusted to pH 7.8. Under optimized separation conditions acceptable levels of linearity, precision and accuracy were obtained for all compounds. The method could be used as part of a cleaning validation study when assaying trace levels of co-trimoxazole drug, some of its decomposition products and detergent in the swab samples collected from pharmaceutical manufacturing equipment, after cleaning DA - 2008-03 DB - ResearchSpace DP - CSIR KW - Micellar electrokinetic chromatography KW - MEKC KW - Pharmaceutical manufacturing equipment KW - Active pharmaceutical ingredients KW - APIs KW - Drug residue KW - Sulfamethoxazole KW - SMZ KW - Trimethoprim KW - TMP LK - https://researchspace.csir.co.za PY - 2008 SM - 0731-7085 T1 - Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment TI - Assessment of MEKC suitability for residue drug monitoring on pharmaceutical manufacturing equipment UR - http://hdl.handle.net/10204/3368 ER - en_ZA


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