The objective of this project was to explore the encapsulation of mycolic acids into vehicles other than liposomes for delivery into macrophages and addressing the challenges of low solubility. As vehicles nanoparticles (NP) have the advantage over liposomes in that they can increase the stability of the drug as well as effect controlled release of the agent as a function of in vivo particle degradation.
Reference:
Benadie, Y, Semete, B, Venter, L et al. 2008. Nanoencapsulation of mycolic acids as a deliverable to macrophages. Science Real and Relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008, pp 1
Benadie, Y., Semete, B., Venter, L., Kalombo, L., Driver, C., Jones, A., ... Verschoor, J. (2008). Nanoencapsulation of mycolic acids as a deliverable to macrophages - 2nd CSIR Biennial Conference. CSIR. http://hdl.handle.net/10204/2746
Benadie, Y, B Semete, L Venter, Lonji Kalombo, C Driver, AT Jones, H Swai, and JA Verschoor. "Nanoencapsulation of mycolic acids as a deliverable to macrophages - 2nd CSIR Biennial Conference." (2008): http://hdl.handle.net/10204/2746
Benadie Y, Semete B, Venter L, Kalombo L, Driver C, Jones A, et al, Nanoencapsulation of mycolic acids as a deliverable to macrophages - 2nd CSIR Biennial Conference; CSIR; 2008. http://hdl.handle.net/10204/2746 .
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