dc.contributor.author |
Mo, L
|
en_US |
dc.contributor.author |
Avci, B
|
en_US |
dc.contributor.author |
James, D
|
en_US |
dc.contributor.author |
Simpson, B
|
en_US |
dc.contributor.author |
Van Wyngaardt, WM
|
en_US |
dc.contributor.author |
Cessna, JT
|
en_US |
dc.contributor.author |
Baldock, C
|
en_US |
dc.date.accessioned |
2007-02-07T06:06:40Z |
en_US |
dc.date.accessioned |
2007-06-07T10:01:52Z |
|
dc.date.available |
2007-02-07T06:06:40Z |
en_US |
dc.date.available |
2007-06-07T10:01:52Z |
|
dc.date.copyright |
|
en_US |
dc.date.issued |
2005-08 |
en_US |
dc.identifier.citation |
Mo, L, et al. 2005. Development of activity standard for 90Y microspheres. Applied Radiation and Isotopes, vol 63(2), pp 193-199 |
en_US |
dc.identifier.issn |
0969-8043 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/10204/1572
|
en_US |
dc.identifier.uri |
http://hdl.handle.net/10204/1572
|
|
dc.description.abstract |
90Y is a therapeutic radiopharmaceuticals used in the treatment of liver cancer following implantation via a catheter in the hepatic artery, 90Y microspheres are embolised in the microvasculature of liver cancer where they irradiate the tumour by a process known as selective internal radiation therapy. SIR-spheres are radiopharmaceutical products that are comprised of 90Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres production the capability of accurately measuring the activity of this product to a traceable national measurement standard. In the SIR-spheres product, the microspheres are non-biodegradable plastic beads, which have a density of 1.0 g/ml and a diameter of approximately 35 mm. 90Y used was the nuclear reactor-produced radionuclide. The concentration of the microspheres is approximately 40% and patient doses of SIR- product are usually prepared in a Wheaton vial by ARI with an activity of 3 GBq in a volume of 5 ml. The direct standard transfer is limited to a small quantity of SIR-spheres of about 1ml due to the difficulty of effectively digesting a large quantity of SIR-spheres such as 5 ml. The calibration factor for 5ml SIR-spheres may be derived from the factor for 1ml SIR-spheres, although relatively large uncertainty may be introduced due to the inhomogeneity of activity concentration dispensed into 1 and 5ml samples. |
en_US |
dc.format.extent |
226672 bytes |
en_US |
dc.format.mimetype |
application/pdf |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Pergamon-Elsevier Science Ltd |
en_US |
dc.rights |
Copyright: 2004 Pergamon-Elsevier Science Ltd |
en_US |
dc.source |
|
en_US |
dc.subject |
90Y microspheres |
en_US |
dc.subject |
Selective internal radiation therapy |
en_US |
dc.subject |
Calibration factors |
en_US |
dc.subject |
Inorganic chemistry |
en_US |
dc.subject |
Medical sciences |
en_US |
dc.subject |
Radiology |
en_US |
dc.subject |
SIR spheres |
en_US |
dc.title |
Development of activity standard for 90Y microspheres |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Mo, L., Avci, B., James, D., Simpson, B., Van Wyngaardt, W., Cessna, J., & Baldock, C. (2005). Development of activity standard for 90Y microspheres. http://hdl.handle.net/10204/1572 |
en_ZA |
dc.identifier.chicagocitation |
Mo, L, B Avci, D James, B Simpson, WM Van Wyngaardt, JT Cessna, and C Baldock "Development of activity standard for 90Y microspheres." (2005) http://hdl.handle.net/10204/1572 |
en_ZA |
dc.identifier.vancouvercitation |
Mo L, Avci B, James D, Simpson B, Van Wyngaardt W, Cessna J, et al. Development of activity standard for 90Y microspheres. 2005; http://hdl.handle.net/10204/1572. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Mo, L
AU - Avci, B
AU - James, D
AU - Simpson, B
AU - Van Wyngaardt, WM
AU - Cessna, JT
AU - Baldock, C
AB - 90Y is a therapeutic radiopharmaceuticals used in the treatment of liver cancer following implantation via a catheter in the hepatic artery, 90Y microspheres are embolised in the microvasculature of liver cancer where they irradiate the tumour by a process known as selective internal radiation therapy. SIR-spheres are radiopharmaceutical products that are comprised of 90Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres production the capability of accurately measuring the activity of this product to a traceable national measurement standard. In the SIR-spheres product, the microspheres are non-biodegradable plastic beads, which have a density of 1.0 g/ml and a diameter of approximately 35 mm. 90Y used was the nuclear reactor-produced radionuclide. The concentration of the microspheres is approximately 40% and patient doses of SIR- product are usually prepared in a Wheaton vial by ARI with an activity of 3 GBq in a volume of 5 ml. The direct standard transfer is limited to a small quantity of SIR-spheres of about 1ml due to the difficulty of effectively digesting a large quantity of SIR-spheres such as 5 ml. The calibration factor for 5ml SIR-spheres may be derived from the factor for 1ml SIR-spheres, although relatively large uncertainty may be introduced due to the inhomogeneity of activity concentration dispensed into 1 and 5ml samples.
DA - 2005-08
DB - ResearchSpace
DP - CSIR
KW - 90Y microspheres
KW - Selective internal radiation therapy
KW - Calibration factors
KW - Inorganic chemistry
KW - Medical sciences
KW - Radiology
KW - SIR spheres
LK - https://researchspace.csir.co.za
PY - 2005
SM - 0969-8043
T1 - Development of activity standard for 90Y microspheres
TI - Development of activity standard for 90Y microspheres
UR - http://hdl.handle.net/10204/1572
ER -
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en_ZA |