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The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies

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dc.contributor.author Van Wyk, LT
dc.contributor.author Neyt, Nicole C
dc.contributor.author Jugmohan, Jaimee
dc.contributor.author Panayides, Jenny-Lee
dc.contributor.author Riley, DL
dc.date.accessioned 2024-03-19T07:54:20Z
dc.date.available 2024-03-19T07:54:20Z
dc.date.issued 2024-01
dc.identifier.citation Van Wyk, L., Neyt, N.C., Jugmohan, J., Panayides, J. & Riley, D. 2024. The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies. <i>Reaction Chemistry & Engineering, 9.</i> http://hdl.handle.net/10204/13647 en_ZA
dc.identifier.issn 2058-9883
dc.identifier.uri https://doi.org/10.1039/d3re00443k
dc.identifier.uri http://hdl.handle.net/10204/13647
dc.description.abstract Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the treatment of depression, smoking cessation, ADHD and other addictions. Herein, we report our attempts to develop a greener, safer and more sustainable process for the preparation of bupropion hydrochloride employing flow chemistry. The use of obnoxious and corrosive liquid bromine was evaded through the employment of polymer-bound pyridinium tribromide and environmentally questionable solvents NMP and DMF were substituted with greener co-solvent systems with appreciable success. The final telescoped flow process afforded bupropion hydrochloride in a 69% overall yield, with improved process mass intensity, productivity and purity, as well as a reduction in reagents/solvents designated as red or amber in terms of H-codes. en_US
dc.format Fulltext en_US
dc.language.iso en en_US
dc.relation.uri https://pubs.rsc.org/en/content/articlelanding/2024/re/d3re00443k en_US
dc.source Reaction Chemistry & Engineering, 9 en_US
dc.subject Major depressive disorder en_US
dc.subject MDD en_US
dc.subject Clinical depression en_US
dc.subject Bupropion hydrochloride en_US
dc.title The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies en_US
dc.type Article en_US
dc.description.pages 45-57 en_US
dc.description.note This article is licensed under a Creative Commons License en_US
dc.description.cluster Chemicals en_US
dc.description.impactarea Pharmaceutical Technologies en_US
dc.identifier.apacitation Van Wyk, L., Neyt, N. C., Jugmohan, J., Panayides, J., & Riley, D. (2024). The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies. <i>Reaction Chemistry & Engineering, 9</i>, http://hdl.handle.net/10204/13647 en_ZA
dc.identifier.chicagocitation Van Wyk, LT, Nicole C Neyt, Jaimee Jugmohan, Jenny-Lee Panayides, and DL Riley "The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies." <i>Reaction Chemistry & Engineering, 9</i> (2024) http://hdl.handle.net/10204/13647 en_ZA
dc.identifier.vancouvercitation Van Wyk L, Neyt NC, Jugmohan J, Panayides J, Riley D. The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies. Reaction Chemistry & Engineering, 9. 2024; http://hdl.handle.net/10204/13647. en_ZA
dc.identifier.ris TY - Article AU - Van Wyk, LT AU - Neyt, Nicole C AU - Jugmohan, Jaimee AU - Panayides, Jenny-Lee AU - Riley, DL AB - Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the treatment of depression, smoking cessation, ADHD and other addictions. Herein, we report our attempts to develop a greener, safer and more sustainable process for the preparation of bupropion hydrochloride employing flow chemistry. The use of obnoxious and corrosive liquid bromine was evaded through the employment of polymer-bound pyridinium tribromide and environmentally questionable solvents NMP and DMF were substituted with greener co-solvent systems with appreciable success. The final telescoped flow process afforded bupropion hydrochloride in a 69% overall yield, with improved process mass intensity, productivity and purity, as well as a reduction in reagents/solvents designated as red or amber in terms of H-codes. DA - 2024-01 DB - ResearchSpace DP - CSIR J1 - Reaction Chemistry & Engineering, 9 KW - Major depressive disorder KW - MDD KW - Clinical depression KW - Bupropion hydrochloride LK - https://researchspace.csir.co.za PY - 2024 SM - 2058-9883 T1 - The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies TI - The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies UR - http://hdl.handle.net/10204/13647 ER - en_ZA
dc.identifier.worklist 27712 en_US


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