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Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions

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dc.contributor.author Neyt, Nicole C
dc.contributor.author Van der Westhuizen, Johan C
dc.contributor.author Panayides, Jenny-Lee
dc.contributor.author Riley, DL
dc.date.accessioned 2023-04-11T07:03:34Z
dc.date.available 2023-04-11T07:03:34Z
dc.date.issued 2022-03
dc.identifier.citation Neyt, N.C., Van der Westhuizen, J.C., Panayides, J. & Riley, D. 2022. Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions. <i>Reaction Chemistry & Engineering, 7.</i> http://hdl.handle.net/10204/12734 en_ZA
dc.identifier.issn 2058-9883
dc.identifier.uri https://doi.org/10.1039/D1RE00554E
dc.identifier.uri http://hdl.handle.net/10204/12734
dc.description.abstract Ozonolysis is an attractive, efficient, and green means of introducing oxygen containing functionalities using only oxygen and electricity. Unfortunately, safety issues associated with the accumulation of dissolved ozone and potentially explosive ozonides coupled with an oxygen rich reaction atmosphere have limited its integration into large scale process reactions. Herein we report on the development and testing of a prototype flow-based ozonolysis reactor which allows on-the-fly removal of ozone and oxygen negating the need for a downstream degassing step and allowing the continuous processing of intermediate ozonides in a safe manner. The approach lends itself to being able to telescope directly into downstream reactions without concern for the effect of residual ozone and minimises contact between the oxygen rich ozone atmosphere and the reaction mixture. The prototype was shown to remove between 98.5 and 99.7% of residual ozone-oxygen on-the-fly and its performance was demonstrated through the ozonolysis of several alkenes to afford a range of oxygen containing functional groups in good to high yields. en_US
dc.format Fulltext en_US
dc.language.iso en en_US
dc.relation.uri https://pubs.rsc.org/en/content/articlelanding/2022/re/d1re00554e en_US
dc.source Reaction Chemistry & Engineering, 7 en_US
dc.subject On-the-fly en_US
dc.subject Ozonolysis en_US
dc.title Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions en_US
dc.type Article en_US
dc.description.pages 1718-1727 en_US
dc.description.note This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. en_US
dc.description.cluster Chemicals en_US
dc.description.impactarea Pharmaceutical Technologies en_US
dc.identifier.apacitation Neyt, N. C., Van der Westhuizen, J. C., Panayides, J., & Riley, D. (2022). Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions. <i>Reaction Chemistry & Engineering, 7</i>, http://hdl.handle.net/10204/12734 en_ZA
dc.identifier.chicagocitation Neyt, Nicole C, Johan C Van der Westhuizen, Jenny-Lee Panayides, and DL Riley "Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions." <i>Reaction Chemistry & Engineering, 7</i> (2022) http://hdl.handle.net/10204/12734 en_ZA
dc.identifier.vancouvercitation Neyt NC, Van der Westhuizen JC, Panayides J, Riley D. Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions. Reaction Chemistry & Engineering, 7. 2022; http://hdl.handle.net/10204/12734. en_ZA
dc.identifier.ris TY - Article AU - Neyt, Nicole C AU - Van der Westhuizen, Johan C AU - Panayides, Jenny-Lee AU - Riley, DL AB - Ozonolysis is an attractive, efficient, and green means of introducing oxygen containing functionalities using only oxygen and electricity. Unfortunately, safety issues associated with the accumulation of dissolved ozone and potentially explosive ozonides coupled with an oxygen rich reaction atmosphere have limited its integration into large scale process reactions. Herein we report on the development and testing of a prototype flow-based ozonolysis reactor which allows on-the-fly removal of ozone and oxygen negating the need for a downstream degassing step and allowing the continuous processing of intermediate ozonides in a safe manner. The approach lends itself to being able to telescope directly into downstream reactions without concern for the effect of residual ozone and minimises contact between the oxygen rich ozone atmosphere and the reaction mixture. The prototype was shown to remove between 98.5 and 99.7% of residual ozone-oxygen on-the-fly and its performance was demonstrated through the ozonolysis of several alkenes to afford a range of oxygen containing functional groups in good to high yields. DA - 2022-03 DB - ResearchSpace DP - CSIR J1 - Reaction Chemistry & Engineering, 7 KW - On-the-fly KW - Ozonolysis LK - https://researchspace.csir.co.za PY - 2022 SM - 2058-9883 T1 - Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions TI - Design and testing of an ozonolysis reactor module with on-the-fly ozone degassing under flow conditions UR - http://hdl.handle.net/10204/12734 ER - en_ZA
dc.identifier.worklist 26606 en_US


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