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A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy

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dc.contributor.author Thobakgale, Setumo L
dc.contributor.author Ombinda-Lemboumba, Saturnin
dc.contributor.author Mthunzi-Kufa, Patience
dc.date.accessioned 2022-11-06T19:32:09Z
dc.date.available 2022-11-06T19:32:09Z
dc.date.issued 2022-04
dc.identifier.citation Thobakgale, S.L., Ombinda-Lemboumba, S. & Mthunzi-Kufa, P. 2022. A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy. <i>Molecules, 27(8).</i> http://hdl.handle.net/10204/12514 en_ZA
dc.identifier.issn 1420-3049
dc.identifier.uri DOI: 10.3390/molecules27082554
dc.identifier.uri http://hdl.handle.net/10204/12514
dc.description.abstract In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enhancement of the drugs using SERS. Aspirin (10% w/v) and tenofovir (20% v/v) were analysed in the presence of the nanomaterials to determine trends in molecular response to changes in gold/dextran concentrations. Qualitative analysis of the functional groups showed specific trends where the peak area increased with polarizability, electron density and decreased atomic radii. Steric hinderance effects also affected the trends in peak area due to the amount of gold/dextran nanoparticles in solution. Statistical analysis provided accurate and precise linear relationships (R2 = 0.99) for the ester and adenine functional groups of aspirin and tenofovir, respectively. From the above findings, the combined use of gold nano-scaffolds and gold/dextran nanomaterials amplified the Raman signal from the drugs to allow for systematic evaluation of their molecular properties. Although more experiments to correlate the findings are still needed, this SERS approach shows great potential as a screening method in the quality control of medications. en_US
dc.format Fulltext en_US
dc.language.iso en en_US
dc.relation.uri https://pubmed.ncbi.nlm.nih.gov/35458752/ en_US
dc.source Molecules, 27(8) en_US
dc.subject Surface enhanced Raman spectroscopy en_US
dc.subject SERS en_US
dc.subject Chemical sensors en_US
dc.subject Dextran en_US
dc.subject Gold nanoparticles en_US
dc.subject Tenofovir en_US
dc.title A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy en_US
dc.type Article en_US
dc.description.pages 13 en_US
dc.description.note Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). en_US
dc.description.cluster Manufacturing en_US
dc.description.impactarea Biophotonics en_US
dc.identifier.apacitation Thobakgale, S. L., Ombinda-Lemboumba, S., & Mthunzi-Kufa, P. (2022). A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy. <i>Molecules, 27(8)</i>, http://hdl.handle.net/10204/12514 en_ZA
dc.identifier.chicagocitation Thobakgale, Setumo L, Saturnin Ombinda-Lemboumba, and Patience Mthunzi-Kufa "A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy." <i>Molecules, 27(8)</i> (2022) http://hdl.handle.net/10204/12514 en_ZA
dc.identifier.vancouvercitation Thobakgale SL, Ombinda-Lemboumba S, Mthunzi-Kufa P. A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy. Molecules, 27(8). 2022; http://hdl.handle.net/10204/12514. en_ZA
dc.identifier.ris TY - Article AU - Thobakgale, Setumo L AU - Ombinda-Lemboumba, Saturnin AU - Mthunzi-Kufa, Patience AB - In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enhancement of the drugs using SERS. Aspirin (10% w/v) and tenofovir (20% v/v) were analysed in the presence of the nanomaterials to determine trends in molecular response to changes in gold/dextran concentrations. Qualitative analysis of the functional groups showed specific trends where the peak area increased with polarizability, electron density and decreased atomic radii. Steric hinderance effects also affected the trends in peak area due to the amount of gold/dextran nanoparticles in solution. Statistical analysis provided accurate and precise linear relationships (R2 = 0.99) for the ester and adenine functional groups of aspirin and tenofovir, respectively. From the above findings, the combined use of gold nano-scaffolds and gold/dextran nanomaterials amplified the Raman signal from the drugs to allow for systematic evaluation of their molecular properties. Although more experiments to correlate the findings are still needed, this SERS approach shows great potential as a screening method in the quality control of medications. DA - 2022-04 DB - ResearchSpace DP - CSIR J1 - Molecules, 27(8) KW - Surface enhanced Raman spectroscopy KW - SERS KW - Chemical sensors KW - Dextran KW - Gold nanoparticles KW - Tenofovir LK - https://researchspace.csir.co.za PY - 2022 SM - 1420-3049 T1 - A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy TI - A molecular study of aspirin and tenofovir using gold/dextran nanocomposites and surface-enhanced raman spectroscopy UR - http://hdl.handle.net/10204/12514 ER - en_ZA
dc.identifier.worklist 25937 en_US


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