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Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†

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dc.contributor.author Wang, S
dc.contributor.author Panayides, Jenny-Lee
dc.contributor.author Riley, D
dc.contributor.author Tighe, CJ
dc.contributor.author Hii, KK
dc.date.accessioned 2022-03-29T11:15:36Z
dc.date.available 2022-03-29T11:15:36Z
dc.date.issued 2021-09
dc.identifier.citation Wang, S., Panayides, J., Riley, D., Tighe, C. & Hii, K. 2021. Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. <i>Reaction Chemistry & Engineering, 6(11).</i> http://hdl.handle.net/10204/12359 en_ZA
dc.identifier.issn 2058-9883
dc.identifier.uri DOI: 10.1039/d1re00343g
dc.identifier.uri http://hdl.handle.net/10204/12359
dc.description.abstract The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate. en_US
dc.format Abstract en_US
dc.language.iso en en_US
dc.relation.uri https://pubs.rsc.org/en/content/articlelanding/2021/re/d1re00343g en_US
dc.source Reaction Chemistry & Engineering, 6(11) en_US
dc.subject 2-lithio-1-(triphenylmethyl)imidazole en_US
dc.subject Rapid formation en_US
dc.subject Pharmaceutical intermediates en_US
dc.title Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow† en_US
dc.type Article en_US
dc.description.pages 2018-2023 en_US
dc.description.note © The Royal Society of Chemistry 2021. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website: https://pubs.rsc.org/en/content/articlelanding/2021/re/d1re00343g en_US
dc.description.cluster Chemicals en_US
dc.description.impactarea Pharmaceutical Technologies en_US
dc.identifier.apacitation Wang, S., Panayides, J., Riley, D., Tighe, C., & Hii, K. (2021). Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. <i>Reaction Chemistry & Engineering, 6(11)</i>, http://hdl.handle.net/10204/12359 en_ZA
dc.identifier.chicagocitation Wang, S, Jenny-Lee Panayides, D Riley, CJ Tighe, and KK Hii "Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†." <i>Reaction Chemistry & Engineering, 6(11)</i> (2021) http://hdl.handle.net/10204/12359 en_ZA
dc.identifier.vancouvercitation Wang S, Panayides J, Riley D, Tighe C, Hii K. Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. Reaction Chemistry & Engineering, 6(11). 2021; http://hdl.handle.net/10204/12359. en_ZA
dc.identifier.ris TY - Article AU - Wang, S AU - Panayides, Jenny-Lee AU - Riley, D AU - Tighe, CJ AU - Hii, KK AB - The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate. DA - 2021-09 DB - ResearchSpace DP - CSIR J1 - Reaction Chemistry & Engineering, 6(11) KW - 2-lithio-1-(triphenylmethyl)imidazole KW - Rapid formation KW - Pharmaceutical intermediates LK - https://researchspace.csir.co.za PY - 2021 SM - 2058-9883 T1 - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow† TI - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow† UR - http://hdl.handle.net/10204/12359 ER - en_ZA
dc.identifier.worklist 25437 en_US


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