dc.contributor.author |
Adeleke, Oluwatoyin A
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|
dc.contributor.author |
Tsai, P
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|
dc.contributor.author |
Karry, KM
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|
dc.contributor.author |
Monama, Nkwe O
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|
dc.contributor.author |
Michniak-Kohn, BB
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|
dc.date.accessioned |
2021-11-26T08:15:26Z |
|
dc.date.available |
2021-11-26T08:15:26Z |
|
dc.date.issued |
2021-08 |
|
dc.identifier.citation |
Adeleke, O.A., Tsai, P., Karry, K., Monama, N.O. & Michniak-Kohn, B. 2021. Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization. <i>International Journal of Pharmaceutics, 25.</i> http://hdl.handle.net/10204/12176 |
en_ZA |
dc.identifier.issn |
0378-5173 |
|
dc.identifier.issn |
1873-3476 |
|
dc.identifier.uri |
DOI: 10.1016/j.ijpharm.2018.06.004
|
|
dc.identifier.uri |
http://hdl.handle.net/10204/12176
|
|
dc.description.abstract |
Drug treatment remains the most effective global approach to managing and preventing tuberculosis. This work focuses on formulating and evaluating an optimized polyvinyl alcohol-polyethylene glycol based orodispersible strip containing isoniazid, a first-line anti-tubercular agent. A solvent casting method guided through a Taguchi experimental design was employed in the fabrication, optimization and characterization of the orodispersible strip. The optimized strip was physically amalgamated with a monolayer, uniformly distributed surface geometry. It was 159.2 ± 3.0 µm thick, weighed 36.9 ± 0.3 mg, had an isoniazid load of 99.5 ± 0.8%w/w, disintegration and dissolution times of 17.6 ± 0.9 s and 5.5 ± 0.1 min respectively. In vitro crystallinity, thermal measurements and in silico thermodynamic predictions confirmed the strip's intrinsic miscibility, thermodynamic stability and amorphous nature. A Korsmeyer-Peppas (r = 0.99; n > 1 = 1.07) fitted kinetics typified by an initial burst release of 49.4 ± 1.9% at 4 min and a total of 99.8 ± 3.3% at 30 min was noted. Ex vivo isoniazid permeation through porcine buccal mucosa was bi-phasic and characterized by a 50.4 ± 3.8% surge and 95.6 ± 2.9% at 5 and 120 min respectively. The strip was physicomechanically robust, environmentally stable and non-cytotoxic. |
en_US |
dc.format |
Video |
en_US |
dc.language.iso |
en |
en_US |
dc.relation.uri |
https://www.sciencedirect.com/science/article/pii/S0378517318303958?via%3Dihub |
en_US |
dc.source |
International Journal of Pharmaceutics, 25 |
en_US |
dc.subject |
Buccal absorption |
en_US |
dc.subject |
Experimental design |
en_US |
dc.subject |
Isoniazid |
en_US |
dc.subject |
Monolayer film |
en_US |
dc.subject |
Orodispersible strip |
en_US |
dc.subject |
Tuberculosis |
en_US |
dc.title |
Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization |
en_US |
dc.type |
Article |
en_US |
dc.description.pages |
347-359 |
en_US |
dc.description.note |
© 2018 Elsevier B.V. All rights reserved. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website: https://www.sciencedirect.com/science/article/pii/S0378517318303958?via%3Dihub |
|
dc.description.cluster |
National Integrated Cyber InfraStructure |
en_US |
dc.description.impactarea |
CHPC |
en_US |
dc.identifier.apacitation |
Adeleke, O. A., Tsai, P., Karry, K., Monama, N. O., & Michniak-Kohn, B. (2021). Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization. <i>International Journal of Pharmaceutics, 25</i>, http://hdl.handle.net/10204/12176 |
en_ZA |
dc.identifier.chicagocitation |
Adeleke, Oluwatoyin A, P Tsai, KM Karry, Nkwe O Monama, and BB Michniak-Kohn "Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization." <i>International Journal of Pharmaceutics, 25</i> (2021) http://hdl.handle.net/10204/12176 |
en_ZA |
dc.identifier.vancouvercitation |
Adeleke OA, Tsai P, Karry K, Monama NO, Michniak-Kohn B. Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization. International Journal of Pharmaceutics, 25. 2021; http://hdl.handle.net/10204/12176. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Adeleke, Oluwatoyin A
AU - Tsai, P
AU - Karry, KM
AU - Monama, Nkwe O
AU - Michniak-Kohn, BB
AB - Drug treatment remains the most effective global approach to managing and preventing tuberculosis. This work focuses on formulating and evaluating an optimized polyvinyl alcohol-polyethylene glycol based orodispersible strip containing isoniazid, a first-line anti-tubercular agent. A solvent casting method guided through a Taguchi experimental design was employed in the fabrication, optimization and characterization of the orodispersible strip. The optimized strip was physically amalgamated with a monolayer, uniformly distributed surface geometry. It was 159.2 ± 3.0 µm thick, weighed 36.9 ± 0.3 mg, had an isoniazid load of 99.5 ± 0.8%w/w, disintegration and dissolution times of 17.6 ± 0.9 s and 5.5 ± 0.1 min respectively. In vitro crystallinity, thermal measurements and in silico thermodynamic predictions confirmed the strip's intrinsic miscibility, thermodynamic stability and amorphous nature. A Korsmeyer-Peppas (r = 0.99; n > 1 = 1.07) fitted kinetics typified by an initial burst release of 49.4 ± 1.9% at 4 min and a total of 99.8 ± 3.3% at 30 min was noted. Ex vivo isoniazid permeation through porcine buccal mucosa was bi-phasic and characterized by a 50.4 ± 3.8% surge and 95.6 ± 2.9% at 5 and 120 min respectively. The strip was physicomechanically robust, environmentally stable and non-cytotoxic.
DA - 2021-08
DB - ResearchSpace
DP - CSIR
J1 - International Journal of Pharmaceutics, 25
KW - Buccal absorption
KW - Experimental design
KW - Isoniazid
KW - Monolayer film
KW - Orodispersible strip
KW - Tuberculosis
LK - https://researchspace.csir.co.za
PY - 2021
SM - 0378-5173
SM - 1873-3476
T1 - Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization
TI - Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization
UR - http://hdl.handle.net/10204/12176
ER - |
en_ZA |
dc.identifier.worklist |
25111 |
en_US |