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Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra

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dc.contributor.author Mzondo, Buntubonke
dc.contributor.author Dlamini, Nomusa
dc.contributor.author Malan, FP
dc.contributor.author Labuschagne, Philip W
dc.contributor.author Bovilla, VR
dc.contributor.author Madhunapantula, SV
dc.contributor.author Maharaj, V
dc.date.accessioned 2021-10-04T09:12:58Z
dc.date.available 2021-10-04T09:12:58Z
dc.date.issued 2021-06
dc.identifier.citation Mzondo, B., Dlamini, N., Malan, F., Labuschagne, P.W., Bovilla, V., Madhunapantula, S. & Maharaj, V. 2021. Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. <i>Phytochemistry Letters, 43.</i> http://hdl.handle.net/10204/12119 en_ZA
dc.identifier.issn 1874-3900
dc.identifier.issn 1876-7486
dc.identifier.uri https://doi.org/10.1016/j.phytol.2021.03.001
dc.identifier.uri http://hdl.handle.net/10204/12119
dc.description.abstract Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549). en_US
dc.format Abstract en_US
dc.language.iso en en_US
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1874390021000410 en_US
dc.source Phytochemistry Letters, 43 en_US
dc.subject Cleome gynandra en_US
dc.subject Color ectal cancer en_US
dc.subject Damm ar ane triterpernoids en_US
dc.subject Breast cancer en_US
dc.subject Lung cancer en_US
dc.title Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra en_US
dc.type Article en_US
dc.description.pages 16-22 en_US
dc.description.note Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website: https://www.sciencedirect.com/science/article/pii/S1874390021000410 en_US
dc.description.cluster Chemicals en_US
dc.description.cluster Advanced Agriculture & Food en_US
dc.description.impactarea Unknown en_US
dc.description.impactarea Agro processing en_US
dc.description.impactarea Advanced Functional Materials en_US
dc.identifier.apacitation Mzondo, B., Dlamini, N., Malan, F., Labuschagne, P. W., Bovilla, V., Madhunapantula, S., & Maharaj, V. (2021). Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. <i>Phytochemistry Letters, 43</i>, http://hdl.handle.net/10204/12119 en_ZA
dc.identifier.chicagocitation Mzondo, Buntubonke, Nomusa Dlamini, FP Malan, Philip W Labuschagne, VR Bovilla, SV Madhunapantula, and V Maharaj "Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra." <i>Phytochemistry Letters, 43</i> (2021) http://hdl.handle.net/10204/12119 en_ZA
dc.identifier.vancouvercitation Mzondo B, Dlamini N, Malan F, Labuschagne PW, Bovilla V, Madhunapantula S, et al. Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. Phytochemistry Letters, 43. 2021; http://hdl.handle.net/10204/12119. en_ZA
dc.identifier.ris TY - Article AU - Mzondo, Buntubonke AU - Dlamini, Nomusa AU - Malan, FP AU - Labuschagne, Philip W AU - Bovilla, VR AU - Madhunapantula, SV AU - Maharaj, V AB - Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549). DA - 2021-06 DB - ResearchSpace DP - CSIR J1 - Phytochemistry Letters, 43 KW - Cleome gynandra KW - Color ectal cancer KW - Damm ar ane triterpernoids KW - Breast cancer KW - Lung cancer LK - https://researchspace.csir.co.za PY - 2021 SM - 1874-3900 SM - 1876-7486 T1 - Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra TI - Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra UR - http://hdl.handle.net/10204/12119 ER - en_ZA
dc.identifier.worklist 24921 en_US


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