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Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution

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dc.contributor.author Mandiwana, Vusani
dc.contributor.author Kalombo, Lonji
dc.contributor.author Hayeshi, R
dc.contributor.author Zeevaart, JR
dc.contributor.author Ebenhan, T
dc.date.accessioned 2021-05-19T11:02:22Z
dc.date.available 2021-05-19T11:02:22Z
dc.date.issued 2021-04
dc.identifier.citation Mandiwana, V., Kalombo, L., Hayeshi, R., Zeevaart, J. & Ebenhan, T. 2021. Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. <i>Molecules, 26(9).</i> http://hdl.handle.net/10204/12014 en_ZA
dc.identifier.issn 1420-3049
dc.identifier.uri DOI: 10.3390/molecules26092650
dc.identifier.uri http://hdl.handle.net/10204/12014
dc.description.abstract It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results. en_US
dc.format Fulltext en_US
dc.language.iso en en_US
dc.relation.uri https://pubmed.ncbi.nlm.nih.gov/33946599/ en_US
dc.relation.uri https://www.mdpi.com/1420-3049/26/9/2650 en_US
dc.source Molecules, 26(9) en_US
dc.subject 68Ga en_US
dc.subject PSMA-617 en_US
dc.subject [68Ga]Ga-PSMA-617-ME en_US
dc.subject Biodistribution en_US
dc.subject In vivo en_US
dc.subject MicroPET/CT en_US
dc.subject Prostate cancer en_US
dc.subject PSMA-617 en_US
dc.subject Toxicity en_US
dc.title Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution en_US
dc.type Article en_US
dc.description.pages 16 en_US
dc.description.note opyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). en_US
dc.description.cluster Chemicals en_US
dc.description.impactarea Advanced Functional Materials en_US
dc.identifier.apacitation Mandiwana, V., Kalombo, L., Hayeshi, R., Zeevaart, J., & Ebenhan, T. (2021). Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. <i>Molecules, 26(9)</i>, http://hdl.handle.net/10204/12014 en_ZA
dc.identifier.chicagocitation Mandiwana, Vusani, Lonji Kalombo, R Hayeshi, JR Zeevaart, and T Ebenhan "Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution." <i>Molecules, 26(9)</i> (2021) http://hdl.handle.net/10204/12014 en_ZA
dc.identifier.vancouvercitation Mandiwana V, Kalombo L, Hayeshi R, Zeevaart J, Ebenhan T. Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9). 2021; http://hdl.handle.net/10204/12014. en_ZA
dc.identifier.ris TY - Article AU - Mandiwana, Vusani AU - Kalombo, Lonji AU - Hayeshi, R AU - Zeevaart, JR AU - Ebenhan, T AB - It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results. DA - 2021-04 DB - ResearchSpace DP - CSIR J1 - Molecules, 26(9) KW - 68Ga KW - PSMA-617 KW - [68Ga]Ga-PSMA-617-ME KW - Biodistribution KW - In vivo KW - MicroPET/CT KW - Prostate cancer KW - PSMA-617 KW - Toxicity LK - https://researchspace.csir.co.za PY - 2021 SM - 1420-3049 T1 - Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution TI - Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution UR - http://hdl.handle.net/10204/12014 ER - en_ZA
dc.identifier.worklist 24534 en_US


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