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Browsing Journal Articles by Author "Kalombo, Lonji"

Now showing items 1-17 of 17

99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Grobler, A ; Zeevaart, JR Date: Nov 2018 The aim of this study was to establish the in vivo uptake and tissue distribution of (sup)99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive (sup)99mTc-MDP encapsulated into SLNs was administered to rats ... Read more
Design and formulation of nano-sized spray dried efavirenz. Part I: Influence of formulation parameters

Author: Katata, L ; Tshweu, L ; Naidoo, Saloshnee ; Kalombo, Lonji ; Swai, H Date: Oct 2012 Efavirenz (EFV) is one of the first-line antiretroviral drugs recommended by the World Health Organisation for treating HIV. It is a hydrophobic drug that suffers from low aqueous solubility (4 lg/mL), which leads to a limited oral absorption ... Read more
Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration

Author: Semete, B ; Booysen, L ; Kalombo, Lonji ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study aims to elucidate the ... Read more
Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix

Author: Mlalila, N ; Swai, H ; Kalombo, Lonji ; Hilonga, A Date: Dec 2014 The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using ... Read more
The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system combined drug delivery system

Author: Chelopo, MP ; Kalombo, Lonji ; Wesley-Smith, J ; Grobler, A ; Hayeshi, R Date: Mar 2017 The combination of polymeric nanoparticles (NPs) as a core and lipid vesicles as a shell has emerged to be a robust and promising drug delivery strategy. This study explores the development of a novel combined delivery system where poly d,l, ... Read more
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems

Author: Semete, B ; Booysen, L ; Lemmer, Yolandy ; Kalombo, Lonji ; Katata, L ; Verschoor, J ; Swai, HS Date: Oct 2010 The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some concerns. The aim of ... Read more
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Author: Booysen, LLIJ ; Kalombo, Lonji ; Brooks, E ; Hansen, R ; Gilliland, J ; Gruppo, V ; Lungenhofer, P ; Semete-Makokotlela, Boitumelo ; Swai, HS ; Kotze, AF ; Lenaerts, A ; du Plessis, LH Date: Feb 2013 Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to ... Read more
Micronization, characterization and in-vitro dissolution of shellac from PGSS supercritical CO2 technique

Author: Labuschagne, Philip W ; Naicker, B ; Kalombo, Lonji Date: Feb 2016 The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the particles from gas saturated solution (PGSS) process and ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment

Author: Tshweu, L ; Katata, L ; Kalombo, Lonji ; Swai, H Date: Oct 2013 Current treatments available for human immunodeficiency virus, namely antiretrovirals, do not completely eradicate the virus from the body, leading to life-time commitment. Many antiretrovirals suffer drawbacks from toxicity and unpleasant ... Read more
Permeation of PLGA nanoparticles across different in vitro models

Author: Nkabinde, LA ; Shoba-Zikhali, LN ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, HS ; Hayeshi, R ; Naicker, B ; Hillie, TK ; Hamman, JH Date: Jul 2012 Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake ... Read more
Potential of improving the treatment of tuberculosis through nanomedicine

Author: Semete, B ; Kalombo, Lonji ; Katata, L ; Chelule, P ; Booysen, L ; Lemmer, Yolandy ; Naidoo, Saloshnee ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains ... Read more
Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Hayeshi, R ; Zeevaart, JR ; Ebenhan, T Date: Apr 2021 It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. ... Read more
Preclinical assessment of 68Ga-PSMA-617 entrapped in a microemulsion delivery system for applications in prostate cancer PET/CT imaging

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Lemmer, Yolandy ; Labuschagne, Philip W ; Semete-Makokotlela, Boitumelo ; Sathekge, M ; Ebenhan, T ; Rijn Zeevaart, J Date: Jun 2019 It has in recent years been reported that microemulsion (ME) delivery systems provide an opportunity to improve the efficacy of a therapeutic agent whilst minimising side effects and also offer the advantage of favourable treatment regimens. ... Read more
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles

Author: Omwoyo, WN ; Ogutu, B ; Oloo, F ; Swai, H ; Kalombo, Lonji ; Melariri, P ; Mahanga, GM ; Waweru Gathirwa, JW Date: Aug 2014 Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointe ... Read more
Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles

Author: Mandiwana, V ; Kalombo, Lonji ; Venter, Karien ; Sathekge, M ; Grobler, A ; Zeevaart, JR Date: Sep 2015 Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of this study was to ... Read more
Supercritical antisolvent co-precipitation of rifampicin and ethyl cellulose

Author: Djerafi, R ; Swanepoel, Andri ; Crampon, C ; Kalombo, Lonji ; Labuschagne, Philip W ; Badens, E ; Masmoudi, Y Date: May 2017 Rifampicin-loaded submicron-sized particles were prepared through supercritical anti-solvent process using ethyl cellulose as polymeric encapsulating excipient. Ethyl acetate and a mixture of ethyl acetate/dimethyl sulfoxide (70/30 and 85/15) ... Read more

Now showing items 1-17 of 17

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