Author:Robertson, GJ; Stoychev, Stoyan H; Sayed, Y; Achilonu, I; Dirr, HWDate:Mar 2017Glutathione S-transferase A3-3 is the most catalytically efficient steroid isomerase enzyme known in humans, transforming Δ5-androstene-3-17-dione into Δ4-androstene-3-17-dione. GSTA3-3 catalyzes this reaction with ten-fold greater efficiency ...Read more
Author:Owen, GR; Stoychev, Stoyan H; Achilonu, I; Dirr, HWDate:Mar 2013JNK1 is activated by phosphorylation of the canonical T183 and Y185 residues, modifications that are catalysed typically by the upstream eukaryotic kinases MKK4 and MKK7. Nonetheless, the exact sites at which the most abundant JNK variant, ...Read more
Author:Owen, GR; Stoychev, Stoyan H; Achilonu, I; Dirr, HWDate:Oct 2014Many studies have characterized how changes to the stability and internal motions of a protein during activation can contribute to their catalytic function, even when structural changes cannot be observed. Here, unfolding studies and ...Read more