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99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles

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dc.contributor.author Mandiwana, Vusani
dc.contributor.author Kalombo, Lonji
dc.contributor.author Grobler, A
dc.contributor.author Zeevaart, JR
dc.date.accessioned 2019-03-12T12:39:17Z
dc.date.available 2019-03-12T12:39:17Z
dc.date.issued 2018-11
dc.identifier.citation Mandiwana, V., Kalombo, L., Grobler, A. and Zeevaart, J.R. 2018. 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles. Applied Radiation and Isotopes, vol 141, pp. 51-56 en_US
dc.identifier.issn 0969-8043
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0969804317307005
dc.identifier.uri https://doi.org/10.1016/j.apradiso.2018.08.015
dc.identifier.uri http://hdl.handle.net/10204/10795
dc.description Copyright: 2018 Elsevier. Due to copyright restrictions, the attached PDF file only post print version of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Applied Radiation and Isotopes, vol 141, pp. 51-56 en_US
dc.description.abstract The aim of this study was to establish the in vivo uptake and tissue distribution of (sup)99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive (sup)99mTc-MDP encapsulated into SLNs was administered to rats to trace their biodistribution through imaging and ex vivo studies. As expected IV injected (sup)99mTc-MDP exhibited predominant visual bone uptake and a high localisation of particles in the kidneys (3.87%ID/g) followed by bone (2.66%ID/g). IV administered 99mTc-MDP encapsulated by SLN showed similar uptake than (sup)99mTc-MDP. Orally administrated (sup)99mTc-MDP showed no uptake in any organs except the GI-tract while orally administered (sup)99mTc-MDP-SLN showed distinct transfer of (sup)99mTc-MDP from the GI tract with measurable levels in the kidneys and bone. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Workflow;21681
dc.subject Biodistribution en_US
dc.subject In vivo imaging en_US
dc.subject Solid Lipid Nanoparticles en_US
dc.subject SLNs en_US
dc.subject 99mTc-MDP en_US
dc.title 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles en_US
dc.type Article en_US
dc.identifier.apacitation Mandiwana, V., Kalombo, L., Grobler, A., & Zeevaart, J. (2018). 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles. http://hdl.handle.net/10204/10795 en_ZA
dc.identifier.chicagocitation Mandiwana, Vusani, Lonji Kalombo, A Grobler, and JR Zeevaart "99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles." (2018) http://hdl.handle.net/10204/10795 en_ZA
dc.identifier.vancouvercitation Mandiwana V, Kalombo L, Grobler A, Zeevaart J. 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles. 2018; http://hdl.handle.net/10204/10795. en_ZA
dc.identifier.ris TY - Article AU - Mandiwana, Vusani AU - Kalombo, Lonji AU - Grobler, A AU - Zeevaart, JR AB - The aim of this study was to establish the in vivo uptake and tissue distribution of (sup)99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive (sup)99mTc-MDP encapsulated into SLNs was administered to rats to trace their biodistribution through imaging and ex vivo studies. As expected IV injected (sup)99mTc-MDP exhibited predominant visual bone uptake and a high localisation of particles in the kidneys (3.87%ID/g) followed by bone (2.66%ID/g). IV administered 99mTc-MDP encapsulated by SLN showed similar uptake than (sup)99mTc-MDP. Orally administrated (sup)99mTc-MDP showed no uptake in any organs except the GI-tract while orally administered (sup)99mTc-MDP-SLN showed distinct transfer of (sup)99mTc-MDP from the GI tract with measurable levels in the kidneys and bone. DA - 2018-11 DB - ResearchSpace DP - CSIR KW - Biodistribution KW - In vivo imaging KW - Solid Lipid Nanoparticles KW - SLNs KW - 99mTc-MDP LK - https://researchspace.csir.co.za PY - 2018 SM - 0969-8043 T1 - 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles TI - 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles UR - http://hdl.handle.net/10204/10795 ER - en_ZA


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