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Browsing by Author "Mandiwana, Vusani"

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99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Grobler, A ; Zeevaart, JR Date: Nov 2018 The aim of this study was to establish the in vivo uptake and tissue distribution of (sup)99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive (sup)99mTc-MDP encapsulated into SLNs was administered to rats ... Read more
Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Hayeshi, R ; Zeevaart, JR ; Ebenhan, T Date: Apr 2021 It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. ... Read more
Preclinical assessment of 68Ga-PSMA-617 entrapped in a microemulsion delivery system for applications in prostate cancer PET/CT imaging

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Lemmer, Yolandy ; Labuschagne, Philip W ; Semete-Makokotlela, Boitumelo ; Sathekge, M ; Ebenhan, T ; Rijn Zeevaart, J Date: Jun 2019 It has in recent years been reported that microemulsion (ME) delivery systems provide an opportunity to improve the efficacy of a therapeutic agent whilst minimising side effects and also offer the advantage of favourable treatment regimens. ... Read more

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Browsing by Author "Mandiwana, Vusani"

Browsing by Author "Mandiwana, Vusani"

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